• Login
    View Item 
    •   UMB Digital Archive
    • School, Graduate
    • Theses and Dissertations All Schools
    • View Item
    •   UMB Digital Archive
    • School, Graduate
    • Theses and Dissertations All Schools
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of UMB Digital ArchiveCommunitiesPublication DateAuthorsTitlesSubjectsThis CollectionPublication DateAuthorsTitlesSubjects

    My Account

    LoginRegister

    Statistics

    Display statistics

    The Claustrum: From Top to Bottom

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Thumbnail
    Name:
    White_umaryland_0373D_10988.pdf
    Size:
    7.972Mb
    Format:
    PDF
    Download
    Author
    White, Michael
    0000-0002-7202-7515
    Advisor
    Mathur, Brian N. (Brian Neil)
    Date
    2018
    Embargo until
    2019-03-01
    Type
    dissertation
    
    Metadata
    Show full item record
    Abstract
    Despite much speculation, the function of the claustrum, a thin telencephalic brain nucleus, remains largely unknown. The claustrum is reciprocally connected with seemingly the entire cortical mantle, which motivates hypotheses of claustrum function that include multi-sensory integration and top-down/bottom-up attention. In order to discriminate these hypotheses, we examined the claustrum at multiple levels of analysis in rodents. We find that the claustrum is well-connected with executive areas of cortex, such as anterior cingulate cortex (ACC), and highly responsive to stimulation of ACC inputs in acute brain slices. In contrast, claustrum exhibits less connectivity with and responsivity to inputs from hierarchically lower cortices. Using in vivo circuit monitoring and manipulation, we find that ACC inputs to claustrum and claustrum projection neurons mediate top-down cognitive control relative to other basic brain functions, such as motor control and stimulus-response action strategy. Consistent with a role in cognitive control, claustrum neurons projecting to visual cortices and parietal association cortex faithfully propagate ACC input, and claustrum afferents provide strong excitatory drive across cortical layers. To understand how claustrum processes top-down input, we identified claustrum neuron subtypes using membrane properties and examined claustrum microcircuit responsivity to ACC input. We find that one of two claustrum projection neuron subtypes preferentially burst fires in response to ACC input, that the two subtypes differentially target cortex, and that recruitment of inhibitory microcircuits constrains claustrum output. These findings support a model wherein claustrum mediates synchronization of cortices for cognitive control.
    Description
    University of Maryland, Baltimore. Neuroscience. Ph.D. 2018
    Keyword
    5CSRTT
    anterior cingulate cortex
    claustrum
    cognitive control
    fiber photometry
    Electrophysiology
    Basal Ganglia
    Gyrus Cinguli
    Optogenetics
    Photometry
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/8192
    Collections
    Theses and Dissertations School of Medicine
    Theses and Dissertations All Schools

    entitlement

     
    DSpace software (copyright © 2002 - 2023)  DuraSpace
    Quick Guide | Policies | Contact Us | UMB Health Sciences & Human Services Library
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.