Scholarship & History
The UMB Digital Archive is a service of the Health Sciences and Human Services Library (HS/HSL) that collects, preserves, and distributes the academic works of the University of Maryland, Baltimore. It is a place that digitally captures the historical record of the campus.
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EAP and COVID-19 2021: Effective Crisis Leadership During COVID-19Both blind denial and conspiracy theories abound in every conversation, but all eyes are looking to leadership to define the course of action. Your response will reverberate through your organization as people take their cue from what they see and hear from you. Of course, you will be instantly criticized regardless of your decisions and, frankly, you cannot control those responses. You CAN control how you lead and that will stand the test of time. The Pine Rest Employee Assistance Program recommends the following crisis communication process – ACT.
Run, Hide, Fight The Case for ‘Common Sense’ Gun ControlI was first introduced to American gun culture in 1960 when I spent six weeks in Wyoming. I was ten years old and spent the summer with my uncle, Cleo “Doc” Davis. Uncle Cleo was a self-identified “cowboy” who was born in Scotts Bluff, Nebraska and raised in Laramie, Wyoming. He served in the Merchant Marine during World War II and trained as a chiropractor on the GI Bill. Following his marriage to my mother’s sister, they settled in Wyoming where he opened a practice. I arrived in Casper, Wyoming, after a two-and-a-half-day train journey. We attended a re-enactment of the Pony Express commemorating the 100th anniversary of the legendary trans-continental Postal rides. As I watched, two riders completed a flawless, albeit furious, exchange of a mail pouch. The crowd whooped and cheered with delight. I quickly learned that Wyoming was far from Brooklyn. It was a summer of new experiences. I visited Yellowstone, attended rodeos, wore cowboy boots, explored alpine forests, and was introduced to the thrill of hunting. Uncle Cleo was a classic outdoorsman. He had grown up hunting and fishing. Each year he would obtain a license and harvest an elk. He would dress out the animal and prepare it for freezing. Elk meat would provide his family protein throughout the year. It was a lifestyle he cherished. He taught me to shoot responsibly, emphasizing safety. Repeatedly, he would remark that “all guns are loaded and every horse kicks.” He also cautioned that one should respect the power of nature. “Out here weather can kill you,” he’d say. These were valuable common sense lessons for a 10-year-old kid from the city. Today, in the wake of multiple school shootings, we teach 10-year-olds to “run, hide, and fight.”
Novel Myh11 Dual Reporter Mouse Model Provides Definitive Labeling and Identification of Smooth Muscle Cells - Brief ReportObjective: Myh11 encodes a myosin heavy chain protein that is specifically expressed in smooth muscle cells (SMCs) and is important for maintaining vascular wall stability. The goal of this study is to generate a Myh11 dual reporter mouse line for definitive visualization of MYH11+SMCs in vivo. Approach and Results: We generated a Myh11 knock-in mouse model by inserting LoxP-nlacZ-4XpolyA-LoxP-H2B-GFP-polyA-FRT-Neo-FRT reporter cassette into the Myh11 gene locus. The nuclear (n) lacZ-4XpolyA cassette is flanked by 2 LoxP sites followed by H2B-GFP (histone 2B fused green fluorescent protein). Upon Cre-mediated recombination, nlacZ-stop cassette is removed thereby permitting nucleus localized H2B-GFP expression. Expression of the nuclear localized lacZ or H2B-GFP is under control of the endogenous Myh11 promoter. Nuclear lacZ was expressed specifically in SMCs at embryonic and adult stages. Following germline Cre-mediated deletion of nuclear lacZ, H2B-GFP was specifically expressed in the nuclei of SMCs. Comparison of nuclear lacZ expression with Wnt1Creand Mef2cCremediated-H2B-GFP expression revealed heterogenous origins of SMCs from neural crest and second heart field in the great arteries and coronary vessels adjacent to aortic root. Conclusions: The Myh11 knock-in dual reporter mouse model offers an exceptional genetic tool to visualize and trace the origins of SMCs in mice.
Telestroke Across the Continuum of Care: Lessons from the COVID-19 PandemicWhile use of telemedicine to guide emergent treatment of ischemic stroke is well established, the COVID-19 pandemic motivated the rapid expansion of care via telemedicine to provide consistent care while reducing patient and provider exposure and preserving personal protective equipment. Temporary changes in re-imbursement, inclusion of home office and patient home environments, and increased access to telehealth technologies by patients, health care staff and health care facilities were key to provide an environment for creative and consistent high-quality stroke care. The continuum of care via telestroke has broadened to include prehospital, inter-facility and intra-facility hospital-based services, stroke telerehabilitation, and ambulatory telestroke. However, disparities in technology access remain a challenge. Preservation of reimbursement and the reduction of regulatory burden that was initiated during the public health emergency will be necessary to maintain expanded patient access to the full complement of telestroke services. Here we outline many of these initiatives and discuss potential opportunities for optimal use of technology in stroke care through and beyond the pandemic.