• Login
    View Item 
    •   UMB Digital Archive
    • School of Medicine
    • Center for Vaccine Development and Global Health
    • View Item
    •   UMB Digital Archive
    • School of Medicine
    • Center for Vaccine Development and Global Health
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of UMB Digital ArchiveCommunitiesPublication DateAuthorsTitlesSubjectsThis CollectionPublication DateAuthorsTitlesSubjects

    My Account

    LoginRegister

    Statistics

    Display statistics

    Salmonella enterica serovar Typhi and gallbladder cancer: a case-control study and meta-analysis

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Thumbnail
    Name:
    KoshiolSalmonellaEntericaSerov ...
    Size:
    310.7Kb
    Format:
    PDF
    Download
    Author
    Koshiol, Jill
    Wozniak, Aniela
    Cook, Paz
    Date
    2016-11
    Publisher
    John Wiley & Sons, Inc.
    
    Metadata
    Show full item record
    Abstract
    In Chile, where gallbladder cancer (GBC) rates are high and typhoid fever was endemic until the 1990s, we evaluated the association between Salmonella enterica serovar Typhi (S. Typhi) antibodies and GBC. We tested 39 GBC cases, 40 gallstone controls, and 39 population- based controls for S. Typhi Vi antibodies and performed culture and quantitative polymerase chain reaction for the subset with bile, gallstone, tissue, and stool samples available. We calculated gender and education- adjusted odds ratios (ORs) and 95% confidence intervals (CIs) for the association with GBC. We also conducted a meta- analysis of >1000 GBC cases by combining our results with previous studies. GBC cases were more likely to have high Vi antibody titer levels than combined controls (OR: 4.0, 95% CI: 0.9–18.3), although S. Typhi was not recovered from bile, gallstone, tissue, or stool samples. In our meta- analysis, the summary relative risk was 4.6 (95% CI: 3.1–6.8, Pheterogeneity=0.6) for anti- Vi and 5.0 (95% CI: 2.7–9.3, Pheterogeneity = 0.2) for bile or stool culture. Our results are consistent with the meta- analysis. Despite differences in study methods (e.g., S. Typhi detection assay), most studies found a positive association between S. Typhi and GBC. However, the mechanism underlying this association requires further investigation.
    Description
    Additional authors: Adaniel, Christina; Acevedo, Johanna; Azocar, Lorena; Hsing, Ann W.; Roa, Juan C.; Pasetti, Marcela F.; Miquel, Juan F.; Levine, Myron M.; Ferreccio, Catterina - for the Gallbladder Cancer Chile Working Group
    Citation
    Koshiol, J., Wozniak, A., Cook, P., et al. (2016). Samonella enterica Serovar Typhi and Gallbladder Cancer: A Case-Control Study and Meta-Analysis. Cancer Medicine, 5(11), 3310-3325. DOI: 10.1002/cam4.915
    Keyword
    Vi antibodies
    Gallbladder--Cancer
    Chile
    Epidemiology
    Gallbladder Neoplasms
    Meta-Analysis
    Salmonella typhi
    Typhoid Fever
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/7406
    ae974a485f413a2113503eed53cd6c53
    10.100/cam4.915
    Scopus Count
    Collections
    Center for Vaccine Development and Global Health

    entitlement

     
    DSpace software (copyright © 2002 - 2023)  DuraSpace
    Quick Guide | Policies | Contact Us | UMB Health Sciences & Human Services Library
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.