• Login
    View Item 
    •   UMB Digital Archive
    • School, Graduate
    • Theses and Dissertations All Schools
    • View Item
    •   UMB Digital Archive
    • School, Graduate
    • Theses and Dissertations All Schools
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of UMB Digital ArchiveCommunitiesPublication DateAuthorsTitlesSubjectsThis CollectionPublication DateAuthorsTitlesSubjects

    My Account

    LoginRegister

    Statistics

    Display statistics

    The Protective Effect of Glibenclamide in a Novel Model of Hemorrhagic Encephalopathy of Prematurity

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Thumbnail
    Name:
    Tosun_umaryland_0373D_10522.pdf
    Size:
    2.405Mb
    Format:
    PDF
    Download
    Author
    Tosun, Cigdem
    Advisor
    Simard, J. Marc
    Date
    2014
    Type
    dissertation
    
    Metadata
    Show full item record
    Abstract
    Encephalopathy of prematurity (EP) is common in preterm, low-birth weight infants who require mechanical ventilation. The worst forms of EP include choroid plexus and germinal matrix hemorrhages, which often extend intraventricularly. Survivors suffer life-long cognitive, behavioral and motor (cerebral palsy) abnormalities. A clinically relevant model was developed in the rat that featured tandem insults of transient intra-uterine ischemia (IUI) plus transient postnatal venous hypertension. In utero ischemia upregulates SUR1/Trpm4 channels in endothelial cells, similar to channel upregulation in veins of infants with germinal matrix hemorrhage. When the channels are opened by ATP depletion, endothelial cells undergo cytotoxic edema and injury. This weakens the veins, making them susceptible to rupture during later episodes of venous hypertension. This model incorporates hemorrhages in the choroid plexus and periventricular areas that inciteoxidative and inflammatory responses that cause secondary injury to the surrounding white matter. Aside from the developmental abnormalities in infants with hemorrhagic EP secondary to reduced brain mass, there are associated vestibulomotor abnormalities and cognitive dysfunction. Blockade of the SUR1/Trpm4 channel following in utero ischemia with the selective, potent SUR1 inhibitor, glibenclamide, reduces hemorrhage, inflammation, mortality and loss in brain mass, and improve vestibulomotor and cognitive abnormalities in this model. Treatment with glibenclamide 3-day prior to delivery in pregnant rats that were subjected to IUI may act as effective prophylaxis against periventricular hemorrhage, reduce the severity of developmental delay and, most strikingly, reduce loss of tissue mass associated with hemorrhagic EP.
    Description
    University of Maryland, Baltimore. Neuroscience. Ph.D. 2014
    Keyword
    encephalopathy of prematurity
    prenatal ischemia
    sulfonylurea receptor 1
    Infant, Premature
    Respiration, Artificial--adverse effects
    Sulfonylurea Receptors
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/4085
    Collections
    Theses and Dissertations School of Medicine
    Theses and Dissertations All Schools

    entitlement

     
    DSpace software (copyright © 2002 - 2023)  DuraSpace
    Quick Guide | Policies | Contact Us | UMB Health Sciences & Human Services Library
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.