Pancreatic cancer derived 3D organoids as a clinical tool to evaluate the treatment response
Abstract
Pancreatic cancer (PC) is the fourth leading cause of cancer death in both men and women. The standard of care for patients with locally advanced PC of chemotherapy, stereotactic radiotherapy (RT), or chemo-radiation-therapy has shown highly variable and limited success rates. However, three-dimensional (3D) Pancreatic tumor organoids (PTOs) have shown promise to study tumor response to drugs, and emerging treatments under in vitro conditions. We investigated the potential for using 3D organoids to evaluate the precise radiation and drug dose responses of in vivo PC tumors.Description
The article processing charges (APC) for this open access article were partially funded by the Health Sciences and Human Services Library's Open Access Publishing Fund for Early-Career Researchers.Rights/Terms
Attribution-NonCommercial-NoDerivatives 4.0 InternationalKeyword
chemo-radiation therapytreatment response
Pancreas--Cancer
Chemotherapy
Organoids
Imaging, Three-Dimensional
Drug Therapy
Radiotherapy
Treatment Outcome
Identifier to cite or link to this item
http://hdl.handle.net/10713/20972Collections
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- Creative Commons
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivatives 4.0 International