Pressure injuries resulting from the use of respiratory devices during intubation pose a significant challenge in hospitalized patients, leading to morbidity and increased healthcare costs. This scholarly poster examines evidence-based interventions aimed at preventing pressure injuries associated with endotracheal and nasotracheal tubes. A systematic review and meta-analysis, along with four randomized controlled trials and a retrospective observational study, were analyzed. The findings suggest that interventions such as endotracheal tube stabilization with bandage fixation, barrier dressings, and endotracheal tube fasteners significantly reduce the incidence of pressure injuries. However, the complexity of patient outcomes underscores the need for tailored preventive strategies. Clinical Nurse Leaders (CNLs) play a pivotal role in integrating evidence-based practices into nursing care, advocating for patient-centered approaches, and leading quality improvement initiatives. Moving forward, further research is needed to develop standardized risk assessment tools and advance pressure injury prevention strategies.