Mui, Philip2023-08-182023-08-182023http://hdl.handle.net/10713/20651University of Maryland, Baltimore, School of Dentistry, M.S., 2023Cellular attachment properties of the temporary and prosthetic abutment is one of the important factors for creating optimal peri-implant soft tissue around the implant. Surface modifications appear to play an important role in promoting early healing of the soft tissue around the dental implant, affecting primarily the epithelium, fibroblast, and osteoblast cell behavior. Another strategy to better manage peri-implant and abutment soft tissue integration is to coat the surface with bioactive agents to enhance biocompatibility. Among the most commonly utilized are proteins and peptides. The proposed in-vitro study will provide better insights of surface characteristics for implant-abutment interface by application of the peptide RGD for optimized attachment of peri-implant soft tissue cells. The hypothesis is that application of polydopamine and the peptide RGD on the implant-abutment surface can improve fibroblast early attachment, migration and proliferation, thereby advancing early wound healing and establishing peri-implant soft tissue attachment.en-USDental AbutmentsDental Implant-Abutment DesignDental Implantationdissertation2023-06-12Saito, Hanae