Now showing items 21-40 of 13887

    • Sustainability Champion Series: Ronald Cisneros

      Diloia, Meredith (University of Maryland, Baltimore, 2024-06-25)
    • University of Maryland School of Nursing PhD Program Review, 2023

      University of Maryland, Baltimore. School of Nursing (2024-01-15)
    • Detyrosinated microtubule arrays drive myofibrillar malformations in mdx muscle fibers

      Harriot, Anicca; Altair-Morris, Tessa; Vanegas, Camilo; Kallenbach, Jacob G.; Pinto, Kaylie; Joca, Humberto C.; Moutin, Marie-Jo; Shi, Guoli; Ursitti, Jeanine Anne; Grosberg, Anna; et al. (2024-06-24)
      Altered myofibrillar structure is a consequence of dystrophic pathology that impairs skeletal muscle contractile function and increases susceptibility to contraction injury1–3. In murine Duchenne muscular dystrophy (mdx), myofibrillar alterations are abundant in advanced pathology (>4 months) 1–3, an age where we formerly established densified microtubule (MT) arrays enriched in detyrosinated (deTyr) tubulin as negative disease modifiers impacting cell mechanics and mechanotransduction4,5. Given the essential role of deTyr-enriched MT’s in myofibrillar growth, maintenance, and repair, we examined the increased abundance of these arrays as a potential mechanism for these myofibrillar alterations. Here (see6 ) we find an increase in deTyr-tubulin as an early event in dystrophic pathology (4 weeks) with no evidence myofibrillar alterations. At 16 weeks, we show deTyr-enriched MT arrays significantly densified and co-localized to areas of myofibrillar malformation. Profiling the enzyme complexes responsible for deTyr-tubulin, we identify vasohibin 2 (VASH2) and small vasohibin binding protein (SVBP) significantly elevated in the mdx muscle at 4 wks. Using the genetic increase in VASH2/SVBP expression in 4 wk wild-type mice we find densified deTyrenriched MT arrays that co-segregate with myofibrillar malformations similar to those in the 16 wk mdx. Given that no changes were identified in fibers expressing sfGFP as a control, we conclude that disease-dependent densification of deTyr-enriched MT arrays underscores the altered myofibrillar structure in dystrophic skeletal muscle fibers.
    • Phase 1 Study of Intranasal Fusion Inhibitor RQ-01 for the Treatment of COVID-19

      Kottilil, Shyamasundaran; Kenaston, Kristin; DaSilva-Jardine, Paul; Mitchnick, Mark; Cameron, Kaitlin; Smith, Larry; Recchio, S.; Herce, Henry; Moss, Ronald; Rojas, Luis; et al. (2024-06-13)
    • Comparison of Two Different Blood Incubation and Monitoring Systems

      Smith, Richard Daniel; Paszkiewicz, Gwen; French, Indira; Johnson, J. Kristie (2024-06-10)
      Background: Management of bloodstream infections requires fast and accurate diagnostic testing to better patient outcomes. Blood culture incubation and monitoring systems are critical for identifying positive blood cultures in a timely matter. Reducing incubation time can reduce time to results. Methods: This study compared two blood culture incubation systems and their media, BD BACTEC™ Plus Aerobic/F media (Becton Dickinson) and BacT/Alert®3D FA plus (BioMérieux) to determine their time to detection and recovery rate. In triplicate, 50 matched bacterial strains were inoculated at 10-100 CFU per 0.1ml and incubated on each instrument. Time to positivity was recorded and difference in time to positivity between matched strains was calculated. Wilcoxon signed- rank test was used to calculate significance. Results: All blood cultures were positive within 24 hours. The median time to positivity for all strains was 12 hours and 30 minutes (Interquartile range (IQR): 11:08, 15:55) for BacT/Alert®3D and 11 hours and 13 minutes for BACTEC™ FX (IQR: 10:05, 14:52) (p <0.001) with average difference in time to positivity being 54.6 minutes. For Gram-positive bacteria, median time to positivity was 13 hours and 54 minutes (IQR: 11:44, 16:18) for BacT/Alert®3D and 12 hours and 29 minutes for the BACTEC™ FX (IQR: 10:53, 16:05) (p = 0.02) with an average difference in time to positivity of 57.3 minutes. For Gram- negative bacteria, median time to positivity was 11 hours and 20 minutes (IQR: 10:52, 12:01) for BacT/Alert®3D and 10 hours and 23 minutes for BACTEC™ FX (IQR: 9:37, 11:14) (p < 0.001). Average difference in time to positivity was 61.1 minutes. For fastidious organisms, the median time was 18 hours and 46 minutes for BacT/Alert®3D and 13 hours and 44 minutes for BACTEC™ FX. Conclusions: BACTEC™ FX significantly reduced time to positivity by approximately one hour when compared to BacT/Alert®3D. This reduction in time could improve patient outcomes
    • Development and Validation of a Multiplex Serology Assay for HPV Type-Specific Antibody Detection

      Aslanabadi, Arash; Karimi, Maryam; Powell, Laura; Shutt, Ashley; Crowell, Trevor A.; Bentzen, Søren M.; Cullen, Kevin J.; Kemp, Troy; Pinto, Ligia A.; Schumaker, Lisa; et al. (2024-06-07)
      Human papillomavirus (HPV) is a common viral infection with over 200 identified types, some of which are classified as oncogenic due to their association with various cancers. Among these, HPV16 is notably the most prevalent and is implicated in the majority of cervical cancers, as well as significant proportions of oropharyngeal, anal, penile, vulvar, and vaginal cancers. Prophylactic vaccines, such as the bivalent, quadrivalent, and 9- valent HPV vaccines, are highly effective in preventing infections with the most common oncogenic HPV types. Despite this, vaccine uptake varies globally due to factors such as vaccine availability, cost, cultural acceptance, and lack of awareness. Consequently, many individuals remain unvaccinated and at risk for HPV infection and its associated cancers. Catch-up vaccination programs are essential for reaching those who missed routine vaccination during adolescence. However, identifying individuals who are seronegative for HPV-16 and other oncogenic types is crucial for the efficient allocation of vaccines, especially in resource-limited settings. Current serological assays are often limited in scope and require large sample volumes, making them less practical for widespread use. We aimed to develop a multiplex serology assay that can simultaneously detect antibodies against multiple HPV types from a small sample volume, providing a valuable tool for targeted vaccination strategies. Also, our objective was to test the performance of our HPV type-specific serology assay using an Internationally defined proficiency panel developed at the National Cancer Institute (NCI) Frederick Laboratory
    • The relationship between alcohol consumption and gut microbiome diversity in individuals with AUD and controls

      Doty, Carolyn; Grant-Beurmann, Silvia; Harrington, Valeria; Kelly, Deanna L.; Bennett, Melanie; Leggio, Lorenzo; Brandler, Brian; Brady, Daniel; Rincon, Natalia; Roche, Daniel (2024-06-06)
    • Scholarship Reconsidered: Integrating EDI into Appointment, Promotion and Tenure Guidelines

      Whittaker, Chanel; Oglesby, Amanda; Lebovitz, Lisa; Onukwugha, Eberechukwu (2024)
      The objective was to develop inclusive promotion and tenure (P&T) criteria at the University of Maryland School of Pharmacy (UMSOP) that reflect the UMSOP’s mission and values, recognize the rich potential of diverse faculty and reward a breadth of scholarly excellence.
    • ALL JOKES ASIDE, A CASE FOR CLOZAPINE MICRODOSING

      Richardson, Elizabeth; Reeves, Gloria; McDonald, Kathryn; Ehret, Megan J.; Kelly, Deanna L. (2024-06-06)
    • University of Maryland Faculty of Physic Minutes, 1857-1862

      University of Maryland, Baltimore. School of Medicine (1862)
    • University of Maryland Faculty of Physic Minutes, 1896-1913

      University of Maryland, Baltimore. School of Medicine (1913)
    • Sustainability Champion Series: Olivia Rosser, MSW

      Diloia, Meredith (University of Maryland, Baltimore, 2024-05-23)
    • Early intervention of psychosis for immigrant patients at a psychosis clinic versus an immigrant-centered community clinic

      Schin, Christina; McDonald, Kathryn; Fitzgerald, John; Akbar, Muhammad; Malick, Rida; Hackman, Ann; Okuzawa, Nana; Reeves, Gloria (2024-06-06)
    • University of Maryland Board of Regents Minutes, 1839-1909

      University of Maryland. Board of Regents. (1909)
    • University of Maryland Board of Regents Minutes, 1909-1920

      University of Maryland. Board of Regents, / (1920)
    • Deans' Council of the Baltimore Schools Minutes, 1920-1936

      University of Maryland, Baltimore. Deans' Council (1936)
    • Novel regulation of cell surface membrane proteins through selective autophagy

      Sidibe, Djeneba; Singh, Manisha; Bustos Segura, America J.; Harraz, Maged M. (2024-06-06)