UMB Digital Archive: Recent submissions
Now showing items 1-20 of 14056
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Improved Adherence to Follow-Up Care in the Trauma PatientProblem: Trauma patients discharged from an urban level 1 trauma center are at risk of being lost to follow up care when they are advised to follow up and do not. Interventions around the transition from inpatient to outpatient can positively impact outpatient follow-up rates and decrease readmissions. Purpose: The purpose of this Doctor of Nursing Practice (DNP) quality improvement project was to implement a structured home discharge process that includes scheduling appointments, educating on follow-up appointments, post discharge phone calls, and monitoring of patients who miss their appointments in order to improve adherence to follow-up care in the trauma population. Methods: A structured discharge process that includes the Advanced Practice Providers (APP) requesting an appointment and attaching the updated discharge education, the nurse checking appointments on after-visit summary (AVS) and reviewing clinic discharge education, and the clinic staff contacting patients who did not have a scheduled appointment at discharge or did not complete their scheduled appointment was created and audited throughout the project phase. Results: Appointments scheduled at discharge increased from 28% (n=28) to 62% (n=113), education attached to AVS increased from 86% (n=97) to 92% (n=295), and NRC post discharge phone call answering increased from 38% (n=43) to 46% (n=77). 69 patients where recommended to follow up but did not discharge with an appointment, however, 78% (n=54) were scheduled after discharge. Appointments completion rate was 83% (n=142) post intervention compared to 74% (n=71) pre-intervention. Conclusion: Results show that appointment scheduling, education attached to AVS, answering of NRC post discharge calls, and appointment completion rate all increased with this intervention. There was minimal impact to readmissions, 6% (n=7) at baseline and 7% (n=21) post intervention, as well as lost to follow-up rate, 19% (n=21) at baseline and 18% (n=33) post intervention.
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Implementing Sugammadex Disclosure to Female Patients in the Preoperative and Postoperative SettingProblem: Sugammadex is given to reverse the effects of NMB agents; however, this reversal agent decreases the efficacy of hormonal contraceptives, increasing the risk of unintended pregnancy. At a primary care hospital in Maryland, less than 1% of anesthesia providers correctly completed the sugammadex disclosure form and only 10% of anesthesia providers reported administration of sugammadex intraoperatively during PACU handoff. Purpose: The purpose of this quality improvement initiative was to implement sugammadex disclosure in the postoperative setting and include a completed sugammadex disclosure form in the patient’s discharge packet to all female patients of childbearing age undergoing laparoscopic procedures. Methods: In the months preceding the project, an interdisciplinary team of stakeholders was mobilized to plan evidenced-based structure and workflow changes. Anesthesia and PACU providers were trained on completing the sugammadex disclosure form, reporting intraoperative sugammadex administration, and including the sugammadex disclosure form in the patient discharge instructions. Weekly chart audits were conducted to track project compliance. Approximately eighty female patients of childbearing age were impacted over the implementation period. Results: 60% of PACU and anesthesia providers received in-person training and 100% received electronic communication about the new protocol. The rate of completed sugammadex disclosure forms was 43.5% and 24.7% included the sugammadex disclosure form in patient discharge instructions. Conclusions: Findings suggest low PACU compliance with including sugammadex disclosure in patient discharge instructions. Low compliance may be related to the multi-step process with some steps done electronically and some done on paper. Inclusion of sugammadex disclosure in patient discharge instructions may be increased if added to the electronic health record.
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Improving Patient Experience by Implementing an Evidence-Based Nurse Leader Rounding ToolProblem: An identified clinical unit, in a large community hospital was failing to meet organizational expectations of benchmarked top box scoring on the Hospital Consumer Assessment of Healthcare Providers and Systems (HCAHPS). HCAHPS measures patient experience and impacts hospital reimbursement. The project unit’s HCAHPS score was at 74.4%, versus national top box reporting at 87.4%. Purpose: Intent of this initiative was to optimize service recovery by standardizing and enhancing the unit-based approach to Nurse Leader Rounding (NLR) with the use of a new electronic evidence-based tool to drive process and improve patient experience. It was intended that staff would adopt the project tool to guide their rounding, and that patients would report improved quality of care. The project anticipated that staff would report improved understanding of service recovery and satisfaction with use of a standardized approach. Outcomes were measured by an electronic software solution that patients used to provide real-time feedback on NLR quality and service recovery. Methods: Methodology included assessing participant nurse’s knowledge/ competency, and then implementing formal education for those who conduct unit-based NLR. The project leader, unit educator and nurse manager were identified as key stakeholders. Pre/post review of educational training was analyzed to evaluate feedback. Implementation included establishment of secure data collection plans and baseline data capture. Strategies and tactics to achieve the project goals included training of all staff members who conducted NLR, implementation of an evidence-based best-practice intervention tool, creation of an outcome tool that reflected key questions measured in HCAHPS, and auditing of process with regular team feedback on project outcomes. Patients were given opportunity to provide real-time feedback on the quality of Nurse Leader Rounding. Results: Nurses universally adopted the intervention tool to drive improved process. Patients reported that the quality of NLR improved by at least 25% across all survey questions. Conclusions: Expansion of the evidence-based methodology may yield improved patient experience reporting in similar clinical settings, in key elements of HCAHPS, both at the organization, and potentially beyond.
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Role of cellular effectors in the induction and maintenance of IgA responses leading to protective immunity against enteric bacterial pathogensThe mucosal immune system is a critical first line of defense to infectious diseases, as many pathogens enter the body through mucosal surfaces, disrupting the balanced interactions between mucosal cells, secretory molecules, and microbiota in this challenging microenvironment. The mucosal immune system comprises of a complex and integrated network that includes the gut-associated lymphoid tissues (GALT). One of its primary responses to microbes is the secretion of IgA, whose role in the mucosa is vital for preventing pathogen colonization, invasion and spread. The mechanisms involved in these key responses include neutralization of pathogens, immune exclusion, immune modulation, and cross-protection. The generation and maintenance of high affinity IgA responses require a delicate balance of multiple components, including B and T cell interactions, innate cells, the cytokine milieu (e.g., IL-21, IL-10, TGF-b), and other factors essential for intestinal homeostasis, including the gut microbiota. In this review, we will discuss the main cellular components (e.g., T cells, innate lymphoid cells, dendritic cells) in the gut microenvironment as mediators of important effector responses and as critical players in supporting B cells in eliciting and maintaining IgA production, particularly in the context of enteric infections and vaccination in humans. Understanding the mechanisms of humoral and cellular components in protection could guide and accelerate the development of more effective mucosal vaccines and therapeutic interventions to efficiently combat mucosal infections.
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Staff Mediated Reminder Calls: Reducing Pediatric Cardiology Outpatient NonattendanceProblem Appointment adherence is essential to providing high-quality healthcare. However, missed appointments are common in the outpatient setting. Nonattendance has been shown to decrease quality of care, reduce revenue, and increase healthcare burdens. A pediatric cardiology clinic identified an 18% nonattendance rate. Purpose This quality improvement project implemented staff mediated reminder calls to reduce the nonattendance rate at an urban pediatric cardiology clinic. Methods The project team consisted of a Quality Improvement Project Lead (QI-PL), two scheduling specialists, and a nurse practitioner (NP). Scheduling specialists called patients with an appointment reminder 3-7 days prior to their appointment using a standardized script. Staff assessed and addressed barriers to attendance per clinic policy. Outcome measures were nonattendance rates and reminder call compliance. Additional data was collected for attendance barriers. Results The average nonattendance rate after implementation was 12.02%. This was a 33.22% reduction from the pre-implementation nonattendance rate of 18%. Call compliance averaged 80.55%. The most common barriers to attendance identified were directions to the clinic, language barriers, and insurance coverage. Conclusions Staff mediated reminder calls are a feasible solution to reduce nonattendance.
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Reducing Catheter Insertion Attempts: Implementation of a Difficult Intravenous Access Screening ToolProblem: Cardiac Surgery Intensive Care Unit (CSICU) nurses at a large, academic tertiary care center identified difficulty with peripheral intravenous (PIV) access skill and indicated an average of 3.2 insertion attempts to obtain PIV access. Root cause analysis highlighted nonstandardized training for ultrasound-guided peripheral intravenous (USGPIV) access skill certification and no screening process to identify patients that are difficult for establishing intravenous access (DIVA). Purpose: To implement the Modified Difficult Intravenous Access Scale for Adult Patients (A-DIVA) screening tool to assist CSICU nurses to screen, identify, and risk-stratify DIVA patients. Patients that score moderate- or high-risk for DIVA prompted use of the ultrasound. Project outcome goals were to improve the weekly average of insertion attempts and to improve PIV access first attempt success rates. Methods: Project implementation took place over 15-weeks and impacted 264 patients and 91 nurses. Nurses were trained for A-DIVA screening tool competency and USGPIV champions completed USGPIV access skill training. Nurses utilized the A-DIVA tool for all patients requiring PIV access prior to insertion. Weekly electronic health record (EHR) PIV insertion audits were compared to A-DIVA screening tool data. Project results and updates were disseminated at staff meetings. Results: By the end of implementation, 11 nurses completed formal USGPIV access skill training, 72.5% of nurses completed A-DIVA screening tool competency, and 31.9% of nurses utilized the A-DIVA screening tool. Ultrasound compliance remained 100% throughout implementation. Weekly average patient A-DIVA scores ranged from 3.5/5 – 5/5. Weekly average number of PIV insertion attempts ranged 1 – 3 on the A-DIVA screening tool and 1.1 – 1.8 in the EHR. Weekly average number of PIV insertion attempts remained below the 1.6 attempts goal for 14 of the 15 weeks. Weekly successful PIV first attempts ranged 66.7% – 100% on the A-DIVA screening tool and 60% – 94.1% in the EHR. Weekly successful PIV first attempts in the EHR remained above the 75% goal for 14 of the 15 weeks. Conclusions: Using the protocol, the A-DIVA Tool was a useful tool that assisted CSICU nurses to reduce PIV insertion attempts and improve PIV first attempt success rates in patients moderate- or high-risk for DIVA.
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Implementation Adherence of a Therapy Group Addressing Internalized Stigma Among Psychiatric OutpatientsProblem: Stigma against mental illness brings with it many negative stereotypes that can be internalized by those who live with mental illnesses. The result is called “internalized stigma” or “self-stigma.” The implementation site for this Quality Improvement (QI) project was a 98- patient outpatient clinic providing treatment for schizophrenia-spectrum disorders. An early survey of patients at the site found that nearly half of the patients surveyed (46.94%) experience internalized stigma. There is currently no official treatment approach towards internalized stigma at this site. Purpose: The purpose of this QI project was the implementation of an evidencebased psychoeducational group therapy intervention for the treatment of internalized stigma amongst individuals living with mental illness. The intervention is titled “Ending Self-Stigma” and consists of nine manualized group sessions. Methods: The chosen framework for this QI project was the Promoting Action on Research Implementation in Health Services, or PARIHS model. Implementation included the administration of the nine manualized treatment sessions in addition to one introductory group session and a final feedback session. Attendance at each session as well as availability of each session were measured and analyzed using run charts. Results: Group availability throughout the project implementation period was 100%. Group attendance averaged 94.8%. Program feedback was positive, with participants overwhelmingly reporting enjoyment discussing their experiences with peers. Conclusions: The results show the feasibility and value of implementing this group at the site. High levels of attendance showed patient engagement, and feedback suggested high levels of enjoyment as well as relevance and benefits of the intervention.
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Assessing Adherence to Enhanced Early Warning Score Assessment on the Transplant UnitProblem & Purpose: Patients show subtle changes six to eight hours before clinical deterioration. There was an underutilization of the hospital’s enhanced early warning score (Rapid Evaluation for Safer Care Utilizing Machine Learning and Escalation-RESCUE) in the adult transplant unit in a quaternary care center. This quality improvement initiative aimed to optimize the use of RESCUE through integration into the nurse’s electronic health record (EHR) and report sheets and implementation of a six-hour reassessment with a bedside huddle for critical scores. Methods: Over 15 weeks, bedside nurses reviewed the patient’s RESCUE score during change of shift handoff. This project was expected to affect approximately 45 nurses and 27 patients daily. An updated report sheet to include RESCUE was implemented for 100% of patients. 100% of charge nurses and 90% of the nurses on the unit had RESCUE added to their EHR. Each shift, the charge nurse completed a Research Electronic Data Capture (REDCap) survey to identify if nurses updated the RESCUE score on their handoff sheet. Nurses rechecked the score six hours into their shift and completed the nursing portion of the RESCUE algorithm. The nurse completed a REDCap survey stating their patient’s RESCUE score and huddle interventions. Results: The transplant staff did not use the RESCUE score before implementation. During the implementation phase, there was a 10.5% (n= 551) median compliance rate in RESCUE reassessment compliance. There was an 18% (n= 57) median compliance rate with updating the patient's report sheet. 17 bedside huddles were completed for patients meeting criteria based on the hospital’s algorithm. Conclusions: RESCUE utilization has increased compared to baseline data. Barriers to implementation included staffing shortages and high utilization of agency and float pool nurses. Facilitators of implementation included institutions, management, and charge nurses’ buy-in to the practice change.
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Prevention of Intraoperative Hypothermia for Patients Undergoing Gynecologic SurgeryProblem & Purpose: Intraoperative hypothermia, defined as core body temperature less than 36 degrees Celsius, is an anesthetic complication which can lead to adverse events such as increased risk of infection, delayed emergence, and increased cost to the hospital. Intraoperative hypothermia affected approximately 50% of gynecologic surgical patients at an acute care hospital in Baltimore, Maryland. The purpose of this project was to implement and evaluate the compliance of a preoperative warming protocol among patients undergoing gynecologic procedures. The preoperative warming protocol included the use of forced air warming at the maximum setting for the 30 minutes prior to surgery. The goal of the project was for 100% of eligible patients to receive the warming protocol and for 100% of patients to avoid intraoperative hypothermia. Methods: A team of 17 Certified Registered Nurse Anesthetists, seven physician Anesthesiologists, and 12 Registered Nurses were mobilized to implement the evidence based warming protocol. Education was provided via in person sessions and posted information throughout the preoperative area. Providers were expected to warm all eligible patients for 30 minutes using a forced air warming device immediately prior to the procedure. The anesthesia staff used quick response codes to document use of the protocol and incidence of intraoperative hypothermia. Data was monitored weekly and stored on Research Electronic Data Capture. Results: Overall, a total of 41 patients received the warming protocol over 15 weeks. Anesthesia provider compliance with the protocol was 38.2%. Compliance peaked at 100% in week one and 11. A total of 90.2% of patients who received the warming protocol did not experience intraoperative hypothermia. Conclusion: The data suggests the preoperative warming protocol is effective, feasible, and sustainable. Compliance required ongoing reminders and frequent communication.
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Role of circulating T follicular helper subsets following Ty21a immunization and oral challenge with wild type S. Typhi in humansDespite decades of intense research, our understanding of the correlates of protection against Salmonella Typhi (S. Typhi) infection and disease remains incomplete. T follicular helper cells (TFH), an important link between cellular and humoral immunity, play an important role in the development and production of high affinity antibodies. While traditional TFH cells reside in germinal centers, circulating TFH (cTFH) (a memory subset of TFH) are present in blood. We used specimens from a typhoid controlled human infection model whereby participants were immunized with Ty21a live attenuated S. Typhi vaccine and then challenged with virulent S. Typhi. Some participants developed typhoid disease (TD) and some did not (NoTD), which allowed us to assess the association of cTFH subsets in the development and prevention of typhoid disease. Of note, the frequencies of cTFH were higher in NoTD than in TD participants, particularly 7 days after challenge. Furthermore, the frequencies of cTFH2 and cTFH17, but not cTFH1 subsets were higher in NoTD than TD participants. However, we observed that ex-vivo expression of activation and homing markers were higher in TD than in NoTD participants, particularly after challenge. Moreover, cTFH subsets produced higher levels of S. Typhi-specific responses (cytokines/chemokines) in both the immunization and challenge phases. Interestingly, unsupervised analysis revealed unique clusters with distinct signatures for each cTFH subset that may play a role in either the development or prevention of typhoid disease. Importantly, we observed associations between frequencies of defined cTFH subsets and anti-S. Typhi antibodies. Taken together, our results suggest that circulating TFH2 and TFH17 subsets might play an important role in the development or prevention of typhoid disease. The contribution of these clusters was found to be distinct in the immunization and/or challenge phases. These results have important implications for vaccines aimed at inducing longlived protective T cell and antibody responses.
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Changes in monocyte subsets in volunteers who received an oral wild-type Salmonella Typhi challenge and reached typhoid diagnosis criteriaAn oral Controlled Human Infection Model (CHIM) with wild-type S. Typhi was re-established allowing us to explore the development of immunity. In this model, ~55% of volunteers who received the challenge reached typhoid diagnosis criteria (TD), while ~45% did not (NoTD). Intestinal macrophages are one of the first lines of defense against enteric pathogens. Most organs have selfrenewing macrophages derived from tissue-resident progenitor cells seeded during the embryonic stage; however, the gut lacks these progenitors, and all intestinal macrophages are derived from circulating monocytes. After infecting gut-associated lymphoid tissues underlying microfold (M) cells, S. Typhi causes a primary bacteremia seeding organs of the reticuloendothelial system. Following days of incubation, a second bacteremia and clinical disease ensue. S. Typhi likely interacts with circulating monocytes or their progenitors in the bone marrow. We assessed changes in circulating monocytes after CHIM. The timepoints studied included 0 hours (pre-challenge) and days 1, 2, 4, 7, 9, 14, 21 and 28 after challenge. TD participants provided extra samples at the time of typhoid diagnosis, and 48-96 hours later (referred as ToD). We report changes in Classical Monocytes -CM-, Intermediate Monocytes -IM- and Non-classical Monocytes -NCM-. Changes in monocyte activation markers were identified only in TD participants and during ToD. CM and IM upregulated molecules related to interaction with bacterial antigens (TLR4, TLR5, CD36 and CD206). Of importance, CM and IM showed enhanced binding of S. Typhi. Upregulation of inflammatory molecules like TNF-a were detected, but mechanisms involved in limiting inflammation were also activated (CD163 and CD354 downregulation). CM upregulated molecules to interact/modulate cells of the adaptive immunity, including T cells (HLA-DR, CD274 and CD86) and B cells (CD257). Both CM and IM showed potential to migrate to the gut as integrin a4b7 was upregulated. Unsupervised analysis revealed 7 dynamic cell clusters. Five of these belonged to CM showing that this is the main population activated during ToD. Overall, we provide new insights into the changes that diverse circulating monocyte subsets undergo after typhoid diagnosis, which might be important to control this disease since these cells will ultimately become intestinal macrophages once they reach the gut.
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SAMHSA Overdose Prevention and Response ToolkitThe primary purpose of this Toolkit is to educate a broad audience on overdose causes, risks, and signs, as well as the steps to take when witnessing and responding to an overdose. It provides clear, accessible information on opioid overdose reversal medications, such as naloxone. This Toolkit serves to complement, not replace, training on overdose prevention and response. It is also intended to augment the use of other overdose prevention tools for community engagement and planning, as well as enhance provider education across multiple practice areas. Overdose education and response tools have the greatest impact when focused on people who use drugs because they are most likely to witness and respond to an overdose. However, it is important to recognize that anyone could witness an overdose—whether on the street, at work, at home, in a clinical setting, or in a school. This Toolkit is therefore available for everyone to provide basic knowledge on how to recognize and respond to an overdose.
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Introduction to the International Employee Assistance Digital Archive: A Knowledge HubThis webinar is offered to various EAPA Chapters to introduce them to the International Employee Assistance Digital Archive resources. This particular set of slides introduced this repository to the Georgia EAPA Chapter in the late summer of 2024.
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Supporting Young Minds - Communications Guide and Resourcce GuideMHA Resources Looking for tools to help address and improve youth mental health? Check out Mental Health America’s 2024 #SupportingYoungMinds Resource Guide for info and tools for adults to use in their work with young people! Learn more at mhanational.org/young-minds We’re joining Mental Health America’s #SupportingYoungMinds campaign to help spread the word that empowering young people is key to improving youth mental health. Learn more at mhanational.org/young-minds We encourage you to explore tools for parents and caregivers, school personnel, and other adults in a young person’s life in Mental Health America’s 2024 #SupportingYoungMinds Resource Guide. mhanational.org/young-minds Young people are our future – let’s empower youth voices in mental health! Visit mhanational.org/youth to find information and opportunities for young mental health
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Decreasing the Rate of Seclusion and Restraint Using the Six Core StrategiesProblem: Seclusion and restraint can cause physical injury and psychological harm to both patients and staff, as well as contribute to traumatization of patients. The national average for restraint rate is 0.39 hours per 1,000 patient hours. In March 2022, the project site’s restraint rate was 0.8619 per 1,000 patient hours. From April 2021-March 2022, the project site had only three months where the restraint rate was within 5% variance of the Centers for Medicare and Medicaid Services (CMS) average. Purpose: The purpose of this quality-improvement initiative is to implement a Six-Core Strategy program to modify staff-patient communication and deescalation strategies with the overall goal of reducing seclusion and restraint use on a mixed disorders adult inpatient psychiatric unit. Methods: The initiative will be implemented over a 15-week period in the fall of 2023. This project will measure the rate of project attendance based on rotating schedule established with project unit manager. The rate of project attendance will be measured by dividing the number of actual program attendees by the number of staff members who were scheduled to participate in each week. The rate of seclusion and restraint will be measured using HBIPS-2 and HBIPS-3 reporting criteria to compare the 15 weeks prior to implementation to the 15 weeks following. Results: The project achieved 100% participation during weeks 1, 4, 7, 10, and 12-15. The majority of staff attended program meetings. HBIPS-2 (90.4%) and HBIPS-3 (37.4%) scores decreased in the 15 weeks after project initiation compared to the 15 weeks prior. Conclusions: A major barrier to implementation is ensuring nursing staff participation, as there are competing demands for patient care. Many staff members would rather be available to their patients than taken away from direct patient care. Staff members that attended reported finding the training useful and worthwhile.
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Implementation Adherence of Malnutrition Screening on Head and Neck Oncology PatientsProblem & Purpose: Lack of a standardized nutritional assessment process for patients with head and neck cancer receiving radiotherapy alone (HNC-R) may lead to undiagnosed malnutrition, interrupted radiotherapy, and increased complications. At a northeastern US academic medical center radiation oncology clinic, usual practice includes arranging dietician team referrals for all patients with HNC who receive chemoradiotherapy. In contrast, audits revealed that only two patients with HNC-R received dietician team referrals in FY 2022. This project aimed to promote early detection of malnutrition for all patients with HNC-R by implementing a standardized nutritional assessment process into the clinic's daily workflow. Methods: Before initiation of this 15-week project, the project lead (PL) educated clinic staff (providers/nurses) on administering a nutritional assessment tool, the Patient- Generated Subjective Global Assessment (PG-SGA) to patients with HNC-R. Staff administered PG-SGA during radiation consults at weeks one, four, and final week of radiotherapy. PG-SGA score > 4 initiated a dietician referral. Clerical staff entered data into the electronic medical record (EMR); PL audited EMR and entered data based on EMR audit on a HIPAA-compliant database server, REDCap®. Results: Staff screened 100% (17/17) of patients. Due to lost data on three patients, EMR documentation of PG-SGA scores occurred for 82% (14/17); 64% (9/14) of patients with HNC-R received dietician referrals. Conclusions: Clinic staff adhered to the new workflow process which increased nutritional assessments and dietician referrals for the target subpopulation within this radiation-oncology clinic.
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Policy Development to Improve the Safety of Pediatric Transport During a DisasterProblem: Children transported by a specialized pediatric critical care transport team, staffed with individuals with pediatric training, have better clinical outcomes and are less likely to deteriorate during transport. A group of national stakeholders involved in disaster response identified deficiencies in the transport of critically injured children following a declared disaster. In the setting of disaster, most children are transported by generalist teams who lack specialized training in pediatric care and transport. Purpose: The purpose of this quality improvement policy project was to identify possible policy solutions for the safe and effective transport of children during a disaster. Methods: The initiative utilized the Centers for Disease Control and Prevention Policy Process to draft a policy to address the purpose of the safe and effective transport of children during a disaster. An environmental scan was conducted with eleven national experts in pediatric critical care transport, using the Centers for Disease Control and Prevention Policy Analysis: Key Questions tool, to inform the following possible policy options to: (1) continue with current practice, (2) modify an existing transport policy, or (3) create an entirely new transport policy. Each option was analyzed to determine feasibility, health, and economic/budgetary impact. Results: Results demonstrated high stakeholder buy-in and willingness to participate in a policy development process. Stakeholders unanimously reported an absence of policy related to pediatric transport following a disaster with a substantial gap in research evidence and identified added value for policy development. Conclusions: Modifying an existing policy for pediatric critical care transport would be the most feasible, with the best economic impact and health benefit. A policy solution is expected to add value and create equitable and timely access to appropriate healthcare to improve outcomes.