Introduction: The pediatric population is at greater risk of adverse drug reactions occurring given the lack of evidence regarding the safety and efficacy of medications as well as the prevalence of off-label medication usage. In April 2020, a list of Key Potentially Inappropriate Drugs in Pediatrics, KIDs List, was published that identified 67 medications and/or drug classes associated with a high risk of adverse drug reactions. The purpose of this study is to describe the use of potentially inappropriate medications based on recommendations from the KIDs List in a commercial insurance dataset. Methods: In this cross-sectional study, pharmacy claims data from a 12 million deidentified member sample sourced from IQVIA PharMetrics Plus from January 2006 – December 2015 was used to determine pediatric medication use. Patients < 18 yrs with at least one prescription claim were included. Medications in the KIDs List were identified in the prescription utilization data and specific ages listed as inappropriate use for each medication were evaluated. Proportions of members receiving medications in the KIDs List were calculated. The primary objective of this study was to quantify prescription use of medications on the KIDs List. Results: There were 3,134,855 pediatric patients from January 2006 to December 2015. Of those, 1,997,526 (63.7%) patients had at least one prescription during their enrollment with 304,181 (15.2%) patients having one prescription claim and 1,693,345 (84.8%) patients having two or more prescription claims. Of the 67 medications and/or drug classes listed on the KIDs list, 60 (89.6%) of them were obtained during the 10-year time period. Of the medications listed in the KIDs List that were classified as avoid in children, the highest prescription volume was for products containing codeine (n=290,727). Of the medications listed in the KIDs List that were classified as caution in children, the highest prescription volumes were for products containing promethazine (n=203,453), lamotrigine (n=88,885), and tramadol (n=15,432). Conclusion: The majority of the medications on the KIDs List have been prescribed in children. Each prescription represents an opportunity to avoid potential harm in a child.