Digital therapeutics—evidence-based apps prescribed for substance use disorders (SUD)— deliver proven, convenient treatment that reduces substance use, supports recovery, and relieves strain on clinicians and emergency services. Yet real-world uptake lags, not from lack of effectiveness, but from implementation hurdles. A landmark study, “Economic Cost of Strategic Implementation Approaches to Increase Uptake of Digital Therapeutics for Substance Use Disorders in a Large Integrated Health System,” published in PLOS Digital Health, provides the first concrete numbers on scaling these tools. Over 50 months across 21 primary care sites in a large integrated health system, strategic implementation (including training, practice facilitation, health coaching, and operations) totaled $748,088—about $25,000 per clinic for basic rollout, up to $48,000 for the most intensive combinations.