Background: Urinary tract infections (UTIs) caused by multi-drug-resistant organisms (MDROs) are a significant concern in skilled nursing facilities (SNFs). Despite the effectiveness of enhanced barrier precautions (EBP) in preventing MDRO transmission, their implementation is often inconsistent in SNFs. Methods: For this quality improvement initiative, an electronic health record (EHR) reminder system was implemented, along with staff education and regular audits, to increase compliance with EBP practices. Results: MDRO-associated UTIs significantly decreased from 41.49% to 9.36% (p < 0.0001). Nurse compliance with EBP throughout the intervention period ranged from 91.94-99.38%. Conclusions: Findings highlight the effectiveness of a multifaceted infection prevention approach, emphasizing the importance of combining technology, staff training, and regular audits to improve infection control practices.