Dynamic bone formation in response to mechanical load is critical for healthy bones. Regarding stimulation of whole-body bone anabolic responses via mechanical loading in mice, there are no robust models. The most commonly used approach is axial loading of a single bone, though an issue with this being that it doesn’t account for systemic changes that can be seen after whole body loading. We tested a physiologically relevant progressive weighted exercise regimen to study mechanical load induced systemic bone formation. We used 3 exercise groups: sedentary, unweighted running wheel and a progressive weighted running wheel. After regimen completion, the mice were euthanized with their long bones dissected. End structural bone parameters and active bone formation rate were quantified. We hypothesize, the progressive weighted exercise would increase bone anabolism, compared to the other groups. Surprisingly, there weren’t significant differences among any parameters between all groups. Both running models had decreases in body mass but increases in food consumption compared to the sedentary. Most parameters of body composition (fat mass, lean mass and bone mass) all decreased with exercise, though the parameters never reached statistical significance. We proposed the lack of bone anabolism in the running models may be due to a caloric deficit. Though not our original goal, these new findings display the significance of calorie sufficiency regarding bone anabolic signals. Further work will modify diet to hopeful reveal bone accrual using this physiologically meaningful, systemic bone loading model.