Introduction: Clear aligner orthodontic treatment provides a more hygienic and esthetic alternative to fixed appliances. Attachments play a crucial role in clear aligner therapy, but prolonged use is associated with plaque accommodation and white spot lesions. Objectives: (1)Develop a novel resin-based antibacterial and remineralizing clear aligner attachment material to reduce white spot lesions during treatment (2) Investigate the material mechanical and physical properties, and antimicrobial capabilities on Streptococcus mutans (S). mutans. Materials and Methods: The resin-based clear aligner attachment material was formulated by adding triethylene glycoldivinylbenzyl ether (TEG-DVBE) and urethane dimethacrylate (UDMA), denoted as (UV), along with 3% of the antibacterial monomer dimethylaminododecyl methacrylate (DMADDM), nano-amorphous calcium phosphate (NACP) and glass fillers at different mass fractions (45%,50%,55%). Transbond LV and Vitremer were selected as commercial controls. Flexural strength, elastic modulus, degree of conversion (DC%) and microhardness, Enamel shear bond CFU, MTT and Lactic acid were evaluated. Results: The experimental groups with glass fillers at 45%,50% and 55% exhibited flexural strength from (109.2±8.6)MPa to (96.4±8.2)MPa, exceeding the ISO standard for resin-based materials. Degree of conversion for all experimental groups ranged from (53.4±2.3)% to (68.3±0.9)% significantly higher than the commercial control (37.1±4.1)% (p<0.05). Enamel shear bond shows no statistical significance difference between all the experimental and the commercial control I. The antibacterial effectiveness for experimental groups with 3% DMADDM showed 6-log CFU reduction and 95% reduction of metabolic activity and 92% lactic acid production. Conclusion: The modified resin based clear aligner attachment material demonstrated excellent antimicrobial activity and remineralizing potential while maintaining good physical and mechanical properties. These qualities may offer enhanced protection against white spots lesions during clear aligner therapy.