Introduction/Background: In response to the evolving landscape of healthcare and advancements in technology, the Nursing Informatics Master's Program at the University of Maryland, Baltimore underwent a transformative redesign. This initiative aligns with the 2021 AACN competency-based education (CBE) framework and the 2022 ANA Nursing Informatics Scope and Standards of Practice. The primary aim was to enhance competency-based learning outcomes, integrate hands-on practice engagement, and prepare students to excel in the AI-driven healthcare environment. Methods: The methodology included revising mission and vision statements, redefining program outcomes, benchmarking against peer informatics programs, and conducting market analysis to address emerging trends. Existing curriculum competencies were mapped to AACN essentials and informatics standards, identifying gaps for improvement. A structured, iterative approach scaffolded skill development across courses, optimizing learning experiences. Significant changes included reducing overall credit hours, increasing practicum time to 500 hours, and integrating AI and big data concepts into coursework. Results: Results from this initiative reveal enhanced student preparedness for the challenges of today's technology-rich healthcare environments. The program now emphasizes competency tracking, practical applications, and leadership in innovation, fostering skills vital for improving patient outcomes. Key success factors included collaborative engagement with stakeholders, thorough documentation processes, and leveraging technological tools for curriculum design and implementation. Conclusion: This project exemplifies a commitment to excellence in Nursing Informatics education, paving the way for future advancements and scalability across informatics programs. The outcomes reinforce the critical role of interdisciplinary collaboration in shaping the next generation of informatics professionals.