Background: When compared to the general population, cancer patients are at higher risk for experiencing distress. Undermanaged distress is associated with increased mortality rates, decreased treatment adherence and poorer quality of life. The NCCN Distress Thermometer helps clinicians identify patient stressors and facilitate care. Although most inpatient oncology units at this Comprehensive Cancer Center utilized this tool, this was not a standard practice at the outpatient Transplant Cellular Therapy (TCT) clinic, where 0% of the patients were screened for distress. Purpose: To implement the Distress Thermometer for distress measurement and management among oncology patients at TCT. Methods: Through the 15-week implementation period, nurses screened patients using the Distress Thermometer tool within the EHR. For patients that scored > 4, nurses made referrals to social work and or provider. Weekly chart audits were conducted on a HIPAA protected, VPN server. Collected data included distress screening values and rate of referrals. Results: 88 TCT patients were eligible for screening. Of those eligible, 47 patients (53.4%) had completed distress screenings. All distressed patients received a referral for provider and or social work. Three (37.5%) received social work referrals and seven (87.5%) received provider referrals. Of the seven patients, two did not score significant for distress but requested provider referrals due to questions about their treatment. Conclusions: Implementation of the Distress Thermometer tool led to initiation of distress screening, making of appropriate referrals and improvement of resource utilization. Due to the organization’s plan on implementation of the FACT-BMT tool, it is unlikely that the Distress Thermometer would remain a standard practice at this clinic.