Background: Understanding the impact of serious illness on faith as well as the impact of faith on serious illness in Christians is important in providing support within the faith community and healthcare. Interventions within the faith community are multifold through palliative care, pastoral care, informal volunteer care, prayer, and faith-based programs. Purpose: The aim of this dissertation was to address the gaps in the literature by conducting a phenomenological study to capture the essence of the lived experience in Christians living with serious illness and understand the impact of their spirituality on their illness as well as learn more about their unmet spiritual needs from the spiritual domain of holism. Methods: A phenomenological study was conducted using the Giorgi 5-step method with 20 individuals. These individuals were diagnosed with serious illness a minimum of a year prior to the interview, and were members of a Christian church in Greenwood,, South Carolina located in the Bible Belt of America. Results: Four structures and subsequent constituents resulted from the analysis process. These four were: (1) sovereignty of God with subsequent unpredictability, (2) relationship with God predominantly through prayer, (3) illness-related losses with resulting guilt in the individual for creating additional burden for their caregivers, and (4) gratitude offered by the participants, some through teary expressions, to all who offered love and support throughout their serious illness. The study results provide information about the impact on the spiritual domain in Christians with serious illness as well as the impact of the serious illness on the Christian’s spirituality.