Problem and Purpose: A large academic children’s hospital in the mid-Atlantic region utilizes rapid response teams (RRT) to respond to events requiring urgent assessment and intervention of pediatric patients necessitating admission to the pediatric intensive care unit (PICU) for higher level of care. Numerous studies reveal interfacility transportation of patients and handover of care has been associated with risk of communication failure and compromised patient safety. Anecdotal evidence obtained from the site reports avoidable errors during patient transfer following RRT, including inappropriate blood administration, incorrectly programmed infusions, and occluded or disconnected central lines. However, there is no organizational requirement regarding handover of care between nursing staff. The purpose of this quality improvement initiative is to standardize the exchange of nursing information to decrease the likelihood of communication errors and improve handoff quality for patients admitted to the PICU following rapid response through implementation of a standardized handoff bundle utilizing the evidenced based I-PASS framework. Methods: A standardized nursing handoff comprised of the evidenced- based tool, I-PASS, was developed and utilized for all RRT transfers requiring PICU admission. Complete bundle adherence and adherence to I-PASS was monitored via surveys completed by the admitting nurse, and chart review. Safety events regarding handoff of patient care following RRT reported via the site’s self-report system were monitored during the implementation. Results: 35 patients (n=35) were admitted to the PICU following RRT during implementation. 62.8% of patient transfers utilized the handoff bundle in entirety. 175 total handoff bundle elements were monitored, and 140 elements (80%) were completed. Certain bundle elements had lower levels of omission, including as line, drain, and airway (LDA) assessment, in-person handoff and completion of team synthesis. No safety events regarding patient handover of care following RRT were reported. Conclusions: Development of a collaborative handoff bundle involving the multidisciplinary team can help to enhance patient care during times of increased stress and acuity. Findings suggest that utilization of the I-PASS within a standardized handoff bundle a realistic and practical method to standardize patient handover of care and decrease the risk of communication errors for patients admitted to the PICU following RRT.