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    Antimicrobial activity of Lactobacillus salivarius and Lactobacillus fermentum against Staphylococcus aureus

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    Author
    Kang, M.-S.
    Lim, H.-S.
    Oh, J.-S.
    Date
    2017
    Journal
    Pathogens and Disease
    Publisher
    Oxford University Press
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://www.doi.org/10.1093/femspd/ftx009
    Abstract
    The increasing prevalence of methicillin-resistant Staphylococcus aureus has become a major public health threat. While lactobacilli were recently found useful in combating various pathogens, limited data exist on their therapeutic potential for S. aureus infections. The aim of this study was to determine whether Lactobacillus salivarius was able to produce bactericidal activities against S. aureus and to determine whether the inhibition was due to a generalized reduction in pH or due to secreted Lactobacillus product(s). We found an 8.6-log10 reduction of planktonic and a 6.3-log10 reduction of biofilm S. aureus. In contrast, the previously described anti-staphylococcal effects of L. fermentum only caused a 4.0-log10 reduction in planktonic S. aureus cells, with no effect on biofilm S. aureus cells. Killing of S. aureus was partially pH dependent, but independent of nutrient depletion. Cell-free supernatant that was pH neutralized and heat inactivated or proteinase K treated had significantly reduced killing of L. salivarius than with pH-neutralized supernatant alone. Proteomic analysis of the L. salivarius secretome identified a total of five secreted proteins including a LysM-containing peptidoglycan binding protein and a protein peptidase M23B. These proteins may represent potential novel anti-staphylococcal agents that could be effective against S. aureus biofilms. Copyright Crown 2017.
    Sponsors
    Yvonne Achermann was supported by a 3-year fellowship grant by the Swiss National Science Foundation (SNF) (Switzerland, PBZHP3 141483), and a grant from the Swiss Foundation for Medical-Biological Grants (SSMBS) (Switzerland, P3MP3 148362/1).
    Keyword
    Antibacterial activity
    Biofilm
    Lactobacillus fermentum
    Lactobacillus salivarius
    LysM
    Staphylococcus aureus
    Identifier to cite or link to this item
    https://www.scopus.com/inward/record.uri?eid=2-s2.0-85020319551&doi=10.1093%2ffemspd%2fftx009&partnerID=40&md5=13a367683383dfc310874511a588cb87; http://hdl.handle.net/10713/9989
    ae974a485f413a2113503eed53cd6c53
    10.1093/femspd/ftx009
    Scopus Count
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    UMB Open Access Articles 2017

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