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    The Evidence and Conclusion Ontology (ECO) Supporting GO Annotations

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    Author
    Chibucos, M.C.
    Siegele, D.A.
    Hu, J.C.
    Date
    2017
    Journal
    Methods in Molecular Biology
    Publisher
    Humana Press Inc.
    Type
    Book Chapter
    
    Metadata
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    See at
    https://www.doi.org/10.1007/978-1-4939-3743-1_18
    Abstract
    The Evidence and Conclusion Ontology (ECO) is a community resource for describing the various types of evidence that are generated during the course of a scientific study and which are typically used to support assertions made by researchers. ECO describes multiple evidence types, including evidence resulting from experimental (i.e., wet lab) techniques, evidence arising from computational methods, statements made by authors (whether or not supported by evidence), and inferences drawn by researchers curating the literature. In addition to summarizing the evidence that supports a particular assertion, ECO also offers a means to document whether a computer or a human performed the process of making the annotation. Incorporating ECO into an annotation system makes it possible to leverage the structure of the ontology such that associated data can be grouped hierarchically, users can select data associated with particular evidence types, and quality control pipelines can be optimized. Today, over 30 resources, including the Gene Ontology, use the Evidence and Conclusion Ontology to represent both evidence and how annotations are made. Copyright The Author(s) 2017.
    Sponsors
    This material is based upon work supported by the National Science Foundation under Award Number 1458400 and National Institutes of Health/National Institute of General Medical Sciences under Grant Number 2R01 GM089636. Open Access charges were funded by the University College London Library, the Swiss Institute of Bioinformatics, the Agassiz Foundation, and the Foundation for the University of Lausanne.
    Keyword
    Annotation
    Biocuration
    Conclusion
    Confidence
    Eco
    Evidence
    Experiment
    Inference
    Literature curation
    Quality control
    Identifier to cite or link to this item
    https://www.scopus.com/inward/record.uri?eid=2-s2.0-84994519272&doi=10.1007%2f978-1-4939-3743-1_18&partnerID=40&md5=1cc0643a898ea122e1daf71200796f06; http://hdl.handle.net/10713/9987
    ae974a485f413a2113503eed53cd6c53
    10.1007/978-1-4939-3743-1_18
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