Show simple item record

dc.contributor.authorMcArthur, M.A.
dc.date.accessioned2019-07-15T16:12:17Z
dc.date.available2019-07-15T16:12:17Z
dc.date.issued2017
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85020935794&doi=10.3390%2fv9060143&partnerID=40&md5=adbbb898fc3b131561411d32f26e23ed
dc.identifier.urihttp://hdl.handle.net/10713/9985
dc.description.abstractZika is a rapidly emerging public health threat. Although clinical infection is frequently mild, significant neurological manifestations have been demonstrated in infants born to Zika virus (ZIKV) infected mothers. Due to the substantial ramifications of intrauterine infection, effective counter-measures are urgently needed. In order to develop effective anti-ZIKV vaccines and therapeutics, improved animal models and a better understanding of immunological correlates of protection against ZIKV are required. This review will summarize what is currently known about ZIKV, the clinical manifestations and epidemiology of Zika as well as, the development of animal models to study ZIKV infection, host immune responses against ZIKV, and the current state of development of vaccines and therapeutics against ZIKV. Copyright 2017 by the authors. Licensee MDPI, Basel, Switzerland.en_US
dc.description.sponsorshipThis work was supported, in part, by the Robert Wood Johnson Foundation, Harold Amos Medical Faculty Development Program (73307) and the National Institute of Allergy and Infectious Diseases Cooperative Centers on Human Immunity (NIAID, U19 AI-110820).en_US
dc.description.urihttps://www.doi.org/10.3390/v9060143en_US
dc.language.isoen_USen_US
dc.publisherMDPI AGen_US
dc.relation.ispartofViruses
dc.subjectAnimal modelsen_US
dc.subjectCongenital Zika syndromeen_US
dc.subjectImmunologyen_US
dc.subjectVaccinesen_US
dc.subjectZika virusen_US
dc.titleZika virus: Recent advances towards the development of vaccines and therapeuticsen_US
dc.typeArticleen_US
dc.identifier.doi10.3390/v9060143
dc.identifier.pmid28608813


This item appears in the following Collection(s)

Show simple item record