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    Divergent anomaly in mesocorticolimbic dopaminergic circuits might be associated with different depressive behaviors, an animal study

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    Author
    Bai, M.
    Zhu, X.
    Zhang, L.
    Date
    2017
    Journal
    Brain and Behavior
    Publisher
    John Wiley and Sons Ltd
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://www.doi.org/10.1002/brb3.808
    Abstract
    Background: The mesocorticolimbic dopamine system, which originates from the ventral tegmental area (VTA) and projects primarily to the prefrontal cortex (PFC), olfactory tubercle (OT), nucleus accumbens (NAc), dorsal striatum (ST), and the amygdala (AMy), plays a pivotal role in determining individual motivation and sensitivity to rewards, namely, anhedonia. Not all depressive individuals exhibited anhedonia, thus, it is natural to speculate that the heterogenous manifestations of depression might be related to the mesocorticolimbic dopamine system. Maternal deprivation (MD) and chronic unpredictable stress (CUPS) are two well-established depressogenic stressors, and they were proven to induce different depressive phenotypes. Methods: The depressive and anxiety-like behaviors of MD and CUPS-treated rats were measured by classical behavioral tests including open field, forced swimming, and sucrose preference test. The expression of D1-5 dopamine receptors and DAT mRNA and protein in the mesocorticolimbic dopamine system of rats exposed to MD and CUPS were measured by real-time PCR and Western blot, respectively. Results: Severe anhedonia was observed in MD but not CUPS rats. Divergent expression of D1 and D2 receptors and DAT mRNA and protein in the mesocorticolimbic dopamine system were found between MD and CUPS rats. Significant correlations between different depressive behaviors and D1-/D2-like receptors and DAT protein levels in the mesocorticolimbic dopamine system were observed. Conclusion: Different depressive behaviors of rats such as anhedonia, passive coping behavior, and declined exploratory interest might be related to divergent dopaminergic pathways. Anhedonia is associated with the dysfunction of VTA-NAc and VTA-OT dopaminergic pathways, the passive coping behavior is related to the dysregulation of VTA-PFC and VTA-AMy pathways, and individual exploratory interest is associated with abnormal activity of VTA-PFC and VTA-ST pathways. Copyright 2017 The Authors. Brain and Behavior published by Wiley Periodicals, Inc.
    Sponsors
    This work was supported by National Natural Science Foundation of China (No. 81401118 to M Bai) and National Natural Science Foundation of China (No. 81671341 to X Zhu).
    Keyword
    anhedonia
    chronic unpredictable stress
    DAT
    depressive behaviors
    dopamine receptor
    explorary interest
    maternal deprivation stress
    mesocorticolimbic dopaminergic pathways
    passive coping behavior
    rodents
    Identifier to cite or link to this item
    https://www.scopus.com/inward/record.uri?eid=2-s2.0-85028994147&doi=10.1002%2fbrb3.808&partnerID=40&md5=f6ce75a5da0fca31d6386500dfaf4393; http://hdl.handle.net/10713/9983
    ae974a485f413a2113503eed53cd6c53
    10.1002/brb3.808
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