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dc.contributor.authorSenbanjo, L.T.
dc.contributor.authorChellaiah, M.A.
dc.date.accessioned2019-07-15T16:12:16Z
dc.date.available2019-07-15T16:12:16Z
dc.date.issued2017
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85026812066&doi=10.3389%2ffcell.2017.00018&partnerID=40&md5=008a9dc51fc097950668ed73551e678b
dc.identifier.urihttp://hdl.handle.net/10713/9981
dc.description.abstractCD44 is a cell surface adhesion receptor that is highly expressed in many cancers and regulates metastasis via recruitment of CD44 to the cell surface. Its interaction with appropriate extracellular matrix ligands promotes the migration and invasion processes involved in metastases. It was originally identified as a receptor for hyaluronan or hyaluronic acid and later to several other ligands including, osteopontin (OPN), collagens, and matrix metalloproteinases. CD44 has also been identified as a marker for stem cells of several types. Beside standard CD44 (sCD44), variant (vCD44) isoforms of CD44 have been shown to be created by alternate splicing of the mRNA in several cancer. Addition of new exons into the extracellular domain near the transmembrane of sCD44 increases the tendency for expressing larger size vCD44 isoforms. Expression of certain vCD44 isoforms was linked with progression and metastasis of cancer cells as well as patient prognosis. The expression of CD44 isoforms can be correlated with tumor subtypes and be a marker of cancer stem cells. CD44 cleavage, shedding, and elevated levels of soluble CD44 in the serum of patients is a marker of tumor burden and metastasis in several cancers including colon and gastric cancer. Recent observations have shown that CD44 intracellular domain (CD44-ICD) is related to the metastatic potential of breast cancer cells. However, the underlying mechanisms need further elucidation. Copyright 2017 Senbanjo and Chellaiah.en_US
dc.description.urihttps://www.doi.org/10.3389/fcell.2017.00018en_US
dc.language.isoen_USen_US
dc.publisherFrontiers Media S.A.en_US
dc.relation.ispartofFrontiers in Cell and Developmental Biology
dc.subjectAngiogenesisen_US
dc.subjectCanceren_US
dc.subjectCD44en_US
dc.subjectCD44-ICDen_US
dc.subjectHyaluronic aciden_US
dc.subjectInvasionen_US
dc.subjectMetastasisen_US
dc.subjectMigrationen_US
dc.titleCD44: A multifunctional cell surface adhesion receptor is a regulator of progression and metastasis of cancer cellsen_US
dc.typeArticleen_US
dc.identifier.doi10.3389/fcell.2017.00018


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