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    Androgen receptor regulates the growth of neuroblastoma cells in vitro and in vivo

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    Author
    Sun, J.
    Wang, D.
    Guo, L.
    Date
    2017
    Journal
    Frontiers in Neuroscience
    Publisher
    Frontiers Research Foundation
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://www.doi.org/10.3389/fnins.2017.00116
    Abstract
    Background: Neuroblastoma is the most common extracranial tumors in children. At present about the true etiology of neuroblastoma is unclear and many studies have tried to find effective treatments for these primary malignant tumors. Although it has been illustrated that androgen receptor (AR) was expressed in neuroblastoma cells in some former reports, the biological role of androgen receptor in the development of neuroblastoma is not fully understood. Methods: Androgen (R1881) and the antagonists of androgen receptor (MDV3100 and ARN509) were used to study the role of the androgen receptor signaling pathway in vitro and in vivo on SH-SY5Y and Neuro-2a (N2a) cell lines. Results: We found that AR expression showed an R1881 dose-dependent manner in neuroblastoma cells in vitro and R1881was able to increase, while both antagonists of androgen receptor (MDV3100 and ARN509) significantly decrease, the proliferation, migration, invasion and sphere formation of SH-SY5Y and N2a cells. Moreover, androgen promoted the growth of N2a tumor in vivo. However, when androgen receptor (AR) was effectively knocked down in the two cell lines by siRNA, either promoting or inhibiting effect of the androgen or androgen receptor antagonists, respectively, was attenuated. Conclusion: Our results suggested that androgen receptor may involve in the progression of neuroblastoma as well as provided insight into a new target for the diagnosis and treatment of neuroblastoma patients. Copyright 2017 Sun, Wang, Guo, Fang, Wang and Xing.
    Sponsors
    The study was funded by the National Natural Science Foundation of China (NSFC 31201070) and China Postdoctoral Science Foundation (204001-5) to Yang Wang.
    Keyword
    Androgen receptor
    ARN-509
    Cell proliferation
    MDV3100
    Neuroblastoma
    Identifier to cite or link to this item
    https://www.scopus.com/inward/record.uri?eid=2-s2.0-85017154262&doi=10.3389%2ffnins.2017.00116&partnerID=40&md5=ae7871c48f9504467fcc682a419adde0; http://hdl.handle.net/10713/9976
    ae974a485f413a2113503eed53cd6c53
    10.3389/fnins.2017.00116
    Scopus Count
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    UMB Open Access Articles 2017

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