• Login
    View Item 
    •   UMB Digital Archive
    • UMB Open Access Articles
    • UMB Open Access Articles 2017
    • View Item
    •   UMB Digital Archive
    • UMB Open Access Articles
    • UMB Open Access Articles 2017
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of UMB Digital ArchiveCommunitiesPublication DateAuthorsTitlesSubjectsThis CollectionPublication DateAuthorsTitlesSubjects

    My Account

    LoginRegister

    Statistics

    Display statistics

    Activation of both CB1 and CB2 endocannabinoid receptors is critical for masculinization of the developing medial amygdala and juvenile social play behavior

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Author
    Argue, K.J.
    VanRyzin, J.W.
    Falvo, D.J.
    Date
    2017
    Journal
    eNeuro
    Publisher
    Society for Neuroscience
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://www.doi.org/10.1523/ENEURO.0344-16.2017
    Abstract
    Juvenile social play behavior is a shared trait across a wide variety of mammalian species. When play is characterized by the frequency or duration of physical contact, males usually display more play relative to females. The endocannabinoid system contributes to the development of the sex difference in social play behavior in rats. Treating newborn pups with a nonspecific endocannabinoid agonist, WIN55,212-2, masculinizes subsequent juvenile rough-and-tumble play behavior by females. Here we use specific drugs to target signaling through either the CB1 or CB2 endocannabinoid receptor (CB1R or CB2R) to determine which modulates the development of sex differences in play. Our data reveal that signaling through both CB1R and CB2R must be altered neonatally to modify development of neural circuitry regulating sex differences in play. Neonatal co-agonism of CB1R and CB2R masculinized play by females, whereas co-antagonism of these receptors feminized rates of male play. Because of a known role for the medial amygdala in the sexual differentiation of play, we reconstructed Golgi-impregnated neurons in the juvenile medial amygdala and used factor analysis to identify morphological parameters that were sexually differentiated and responsive to dual agonism of CB1R and CB2R during the early postnatal period. Our results suggest that sex differences in the medial amygdala are modulated by the endocannabinoid system during early development. Sex differences in play behavior are loosely correlated with differences in neuronal morphology. Copyright 2017 Argue et al.
    Keyword
    Amygdala
    Development
    Endocannabinoid
    Juvenile play behavior
    Neuronal morphology
    Rat
    Identifier to cite or link to this item
    https://www.scopus.com/inward/record.uri?eid=2-s2.0-85031895487&doi=10.1523%2fENEURO.0344-16.2017&partnerID=40&md5=c77a660f2b7c1e0b1132e79e8794b76f; http://hdl.handle.net/10713/9973
    ae974a485f413a2113503eed53cd6c53
    10.1523/ENEURO.0344-16.2017
    Scopus Count
    Collections
    UMB Open Access Articles 2017

    entitlement

    Related articles

    • Functional CB2 type cannabinoid receptors at CNS synapses.
    • Authors: Morgan NH, Stanford IM, Woodhall GL
    • Issue date: 2009 Sep
    • Sex difference in cell proliferation in developing rat amygdala mediated by endocannabinoids has implications for social behavior.
    • Authors: Krebs-Kraft DL, Hill MN, Hillard CJ, McCarthy MM
    • Issue date: 2010 Nov 23
    • Microglial Phagocytosis of Newborn Cells Is Induced by Endocannabinoids and Sculpts Sex Differences in Juvenile Rat Social Play.
    • Authors: VanRyzin JW, Marquardt AE, Argue KJ, Vecchiarelli HA, Ashton SE, Arambula SE, Hill MN, McCarthy MM
    • Issue date: 2019 Apr 17
    • [The endocannabinoid system and bone].
    • Authors: Pura M, Vaňuga P
    • Issue date: Fall 2016
    • Cannabinoid type 2 receptors mediate a cell type-specific self-inhibition in cortical neurons.
    • Authors: Stumpf A, Parthier D, Sammons RP, Stempel AV, Breustedt J, Rost BR, Schmitz D
    • Issue date: 2018 Sep 1
    DSpace software (copyright © 2002 - 2021)  DuraSpace
    Quick Guide | Policies | Contact Us | UMB Health Sciences & Human Services Library
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.