Effect of Physical Activity on Self-Reported Disability in Older Adults: Results from the LIFE Study
JournalJournal of the American Geriatrics Society
PublisherBlackwell Publishing Inc.
MetadataShow full item record
AbstractBackground/Objectives: To test the hypothesis that a long‐term structured, moderate intensity physical activity (PA) program is more effective than a health education (HE) program in reducing the risk of s elf‐reported dependency and disability in basic activities of daily living (BADLs), disability in instrumental ADLs (IADL), and mobility disability. Design: The Lifestyle Interventions and Independence for Elders (LIFE) study was a multicenter, single‐blinded randomized trial. Setting: University‐based research clinic. Participants: Thousand six hundred and thirty five sedentary men and women aged 70–89 years, who had functional limitations, defined as a score ≤9 on the Short Physical Performance Battery. Intervention: Participants were randomized to a structured, moderate intensity PA program (n = 818) that included aerobic, resistance, and flexibility exercises or to a HE program (n = 817). Measurements: All outcomes were derived by self‐report using periodic interviews that asked about the degree of difficulty and receipt of help during the past month. Dependency was defined as “receiving assistance” or “unable” to do ≥1 activities. Disability was defined as having “a lot of difficulty” or “unable” doing ≥1 activities. Severe disability was defined as reporting difficulty or being unable to perform ≥3 activities. Results: Over an average follow‐up of 2.6 years, the cumulative incidence of BADL dependency was 15.2% among PA and 15.1% among HE participants (HR = 1.0, 95% CI = 0.78–0.1.3). Intervention groups had similar rates of incident BADL disability, IADL disability and reported mobility disability. Reporting severe mobility disability (HR = 0.78, 95% CI = 0.64–0.96) and ratings of difficulty on mobility tasks were reduced in the PA group. Conclusion: A structured physical activity intervention reduces reported severe mobility disability and difficulty on mobility tasks, but not BADL and IADL disability in older adults with functional limitations. Twenty‐three percent of the United States population, 65+ years of age report having difficulty walking or climbing stairs and 3.6 million older adults report having difficulty with basic activities like dressing and bathing.1 Reporting difficulty with, needing assistance, or being unable to perform daily tasks lead to higher utilization of health care services and loss of physical independence.2 Considerable resources are spent on managing disability among older adults, but there is limited research that evaluates strategies to prevent disability in basic and instrumental activities of daily living. A promising prevention strategy is enhancing physical activity levels, as there is well‐established epidemiological evidence that diminished physical activity is associated with onset of physical disability in older adults.3-6 The Lifestyle Interventions and Independence for Elders (LIFE) Study was a large randomized trial designed to compare the effects of a long‐term, moderate‐intensity physical activity (PA) program with a “successful aging” health education (HE) program.7, 8 The primary outcome of the LIFE study was major mobility disability defined as the loss in the ability to walk 400 m in 15 minutes without help. Here MMD was assessed objectively by observing the ability to walk 400 m. Self‐reported measures of mobility and disability inherently capture a participant's viewpoint of their ability within their own environment. This is a different construct and evaluation of this domain would provide additional insight about the effects of physical activity. The study enrolled inactive older adults 70–89 years of age who were at high risk of disability based on a lower extremity performance test, yet were community dwelling and able to walk 400 m (about a quarter mile) at baseline. Therefore, the sample enrolled in the LIFE study was well‐suited to evaluate the hypothesis that compared to a HE group, a long‐term PA program would prevent the incidence of dependency and disability in basic ADLs (BADLs) as well as disability in instrumental ADLs (IADLs), and reported mobility disability (e.g., walking a quarter mile). Copyright 2017, Copyright the Authors. Journal compilation Copyright 2017, The American Geriatrics Society
SponsorsThe Study is funded by a National Institutes of Health/National Institute on Aging Cooperative Agreement #UO1 AG22376 and a supplement from the National Heart, Lung and Blood Institute 3U01AG022376-05A2S, and sponsored in part by the Intramural Research Program, National Institute on Aging, NIH.
Identifier to cite or link to this itemhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85012960785&doi=10.1111%2fjgs.14742&partnerID=40&md5=7d991178db22faf7d2f5e1d8ba5fb362; http://hdl.handle.net/10713/9971
- Effect of structured physical activity on prevention of major mobility disability in older adults: the LIFE study randomized clinical trial.
- Authors: Pahor M, Guralnik JM, Ambrosius WT, Blair S, Bonds DE, Church TS, Espeland MA, Fielding RA, Gill TM, Groessl EJ, King AC, Kritchevsky SB, Manini TM, McDermott MM, Miller ME, Newman AB, Rejeski WJ, Sink KM, Williamson JD, LIFE study investigators.
- Issue date: 2014 Jun 18
- Hospitalizations During a Physical Activity Intervention in Older Adults at Risk of Mobility Disability: Analyses from the Lifestyle Interventions and Independence for Elders Randomized Clinical Trial.
- Authors: Marsh AP, Applegate WB, Guralnik JM, Jack Rejeski W, Church TS, Fielding RA, Gill TM, King AC, Kritchevsky SB, Manini TM, McDermott MM, Newman AB, Stowe CL, Walkup MP, Pahor M, Miller ME, LIFE Study Investigators.
- Issue date: 2016 May
- Effect of Metabolic Syndrome on the Mobility Benefit of a Structured Physical Activity Intervention-The Lifestyle Interventions and Independence for Elders Randomized Clinical Trial.
- Authors: Botoseneanu A, Chen H, Ambrosius WT, Allore HG, Anton S, Folta SC, King AC, Nicklas BJ, Spring BJ, Strotmeyer ES, Gill TM, LIFE Study Group.
- Issue date: 2017 Jun
- Dose of physical activity, physical functioning and disability risk in mobility-limited older adults: Results from the LIFE study randomized trial.
- Authors: Fielding RA, Guralnik JM, King AC, Pahor M, McDermott MM, Tudor-Locke C, Manini TM, Glynn NW, Marsh AP, Axtell RS, Hsu FC, Rejeski WJ, LIFE study group.
- Issue date: 2017
- Effect of structured physical activity on prevention of serious fall injuries in adults aged 70-89: randomized clinical trial (LIFE Study).
- Authors: Gill TM, Pahor M, Guralnik JM, McDermott MM, King AC, Buford TW, Strotmeyer ES, Nelson ME, Sink KM, Demons JL, Kashaf SS, Walkup MP, Miller ME, LIFE Study Investigators.
- Issue date: 2016 Feb 3