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dc.contributor.authorWei, Y.-J.
dc.contributor.authorSimoni-Wastila, L.
dc.contributor.authorLucas, J.A.
dc.date.accessioned2019-07-15T16:12:15Z
dc.date.available2019-07-15T16:12:15Z
dc.date.issued2017
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85019974754&doi=10.1093%2fgerona%2fglw095&partnerID=40&md5=aaa3dcfae0bd9bc8a6da3060b634d554
dc.identifier.urihttp://hdl.handle.net/10713/9968
dc.description.abstractBackground: Both antidepressants and antipsychotics are used in older adults with behavioral symptoms of Alzheimer's disease and related dementias. Despite the prevalent use of these agents, little is known about their comparative risks for falls and fractures. Methods: Using 2007-2009 Medicare claims data linked to Minimum Data Set 2.0, we identified new users of antidepressants and antipsychotics among nursing home residents with Alzheimer's disease and related dementias who had moderate-to-severe behavioral symptoms. Separate discrete-time survival models were used to estimate risks of falls, fractures, and a composite of both among antidepressant group versus antipsychotic group. Results: Compared to antipsychotic users, antidepressant users experienced significantly higher risk for fractures (adjusted hazard ratio = 1.35, 95% confidence interval = 1.10-1.66). The overall risk of falls or fractures remained significant in the antidepressant versus antipsychotic group (adjusted hazard ratio = 1.16, 95% confidence interval = 1.02-1.32). Conclusions: Antidepressants are associated with higher fall and fracture risk compared to antipsychotics in the management of older adults with Alzheimer's disease and related dementias who experience moderate-to-severe behavioral symptoms. Clinicians need to assess the ongoing risks/benefits of antidepressants for these symptoms especially in light of the increasingly prevalent use of these agents. Copyright The Author 2016.en_US
dc.description.urihttps://www.doi.org/10.1093/gerona/glw095en_US
dc.language.isoen_USen_US
dc.publisherOxford University Pressen_US
dc.relation.ispartofJournals of Gerontology - Series A Biological Sciences and Medical Sciences
dc.subjectAlzheimer's disease and related dementiaen_US
dc.subjectAntidepressantsen_US
dc.subjectAntipsychoticsen_US
dc.subjectFallsen_US
dc.subjectFracturesen_US
dc.titleFall and fracture risk in nursing home residents with moderate-to-severe behavioral symptoms of Alzheimer's disease and related dementias initiating antidepressants or antipsychoticsen_US
dc.typeArticleen_US
dc.identifier.doi10.1093/gerona/glw095
dc.identifier.pmid27247274


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