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    Anti-caries effects of dental adhesives containing quaternary ammonium methacrylates with different chain lengths

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    Author
    Han, Q.
    Li, B.
    Zhou, X.
    Date
    2017
    Journal
    Materials
    Publisher
    MDPI AG
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://www.doi.org/10.3390/ma10060643
    Abstract
    The objectives of this study were to investigate the effects of dental adhesives containing quaternary ammonium methacrylates (QAMs) with different alkyl chain lengths (CL) on ecological caries prevention in vitro. Five QAMs were synthesized with a CL = 3, 6, 9, 12, and 16 and incorporated into adhesives. Micro-tensile bond strength and surface charge density were used to measure the physical properties of the adhesives. The proportion change in three-species biofilms consisting of Streptococcus mutans, Streptococcus sanguinis, and Streptococcus gordonii was tested using the TaqMan real-time polymerase chain reaction. Lactic acid assay, MTT [3-(4,5-dimethyl-thiazol-2-yl)-2,5-diphenyltetrazolium bromide] assay, exopolysaccharide staining, live/dead staining, scanning electron microscopy (SEM), and transverse microradiography (TMR) were performed to study the anti-biofilm and anti-demineralization effects of the dental adhesives. The results showed that incorporating QAMs with different alkyl chain lengths into the adhesives had no obvious effect on the dentin bond strength. The adhesives containing QAMs with a longer alkyl chain developed healthier biofilms. The surface charge density, anti-biofilm, and anti-demineralization effects of the adhesives increased with a CL of the QAMs from 3 to 12, but decreased slightly with a CL from 12 to 16. In conclusion, adhesives containing QAMs with a tailored chain length are promising for preventing secondary caries in an "ecological way". Copyright 2017 by the authors.
    Sponsors
    This study was supported by the International Science and Technology Cooperation Program of China 2014DFE30180 (XZ), the National Natural Science Foundation of China 81372889 (LC), 81430011 (XZ), 81372890 (MF), the Youth Grant of the Science and Technology Department of Sichuan Province, China 2017JQ0028 (L.C.), the Innovative Research Team Program of Sichuan Province, NIH R01 DE17974 (HX), and the University of Maryland School of Dentistry bridge fund (HX).
    Keyword
    Alkyl chain group
    Antibacterial
    Demineralization
    QAMs
    Identifier to cite or link to this item
    https://www.scopus.com/inward/record.uri?eid=2-s2.0-85020416755&doi=10.3390%2fma10060643&partnerID=40&md5=81585acd23f84ed98f85e9ab0cee455c; http://hdl.handle.net/10713/9959
    ae974a485f413a2113503eed53cd6c53
    10.3390/ma10060643
    Scopus Count
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    UMB Open Access Articles 2017

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