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dc.contributor.authorForstera, B.
dc.contributor.authorMunoz, B.
dc.contributor.authorLobo, M.K.
dc.date.accessioned2019-07-15T16:12:14Z
dc.date.available2019-07-15T16:12:14Z
dc.date.issued2017
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85021366601&doi=10.1113%2fJP273767&partnerID=40&md5=07067a5035664877dd3be42f8407dd2d
dc.identifier.urihttp://hdl.handle.net/10713/9957
dc.description.abstractAlcohol abuse causes major social, economic and health‐related problems worldwide. Alcohol, like other drugs of abuse, increases levels of dopamine in the nucleus accumbens (nAc), facilitating behavioural reinforcement and substance abuse. Previous studies suggested that glycine receptors (GlyRs) are involved in the regulation of accumbal dopamine levels. Here, we investigated the presence of GlyRs in accumbal dopamine receptor medium spiny neurons (MSNs) of C57BL/6J mice, analysing mRNA expression levels and immunoreactivity of GlyR subunits, as well as ethanol sensitivity. We found that GlyR α1 subunits are expressed at higher levels than α2, α3 and β in the mouse nAc and were located preferentially in dopamine receptor 1 (DRD1)‐positive MSNs. Interestingly, the glycine‐evoked currents in dissociated DRD1‐positive MSNs were potentiated by ethanol. Also, the potentiation of the GlyR‐mediated tonic current by ethanol suggests that they modulate the excitability of DRD1‐positive MSNs in nAc. This study should contribute to understanding the role of GlyR α1 in the reward system and might help to develop novel pharmacological therapies to treat alcoholism and other addiction‐related and compulsive behaviours. Copyright 2017 The Authors. The Journal of Physiology Copyright 2017 The Physiological Societyen_US
dc.description.urihttps://www.doi.org/10.1113/JP273767en_US
dc.language.isoen_USen_US
dc.publisherBlackwell Publishing Ltden_US
dc.relation.ispartofJournal of Physiology
dc.subjectalcoholen_US
dc.subjectglycine receptorsen_US
dc.subjectnucleus accumbensen_US
dc.titlePresence of ethanol-sensitive glycine receptors in medium spiny neurons in the mouse nucleus accumbensen_US
dc.typeArticleen_US
dc.identifier.doi10.1113/JP273767
dc.identifier.pmid28524260


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