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dc.contributor.authorMunzel, T.
dc.contributor.authorSørensen, M.
dc.contributor.authorGori, T.
dc.date.accessioned2019-07-15T16:12:13Z
dc.date.available2019-07-15T16:12:13Z
dc.date.issued2017
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85016261401&doi=10.1093%2feurheartj%2fehw294&partnerID=40&md5=69f21df6884b556a5e88c61917ef05bc
dc.identifier.urihttp://hdl.handle.net/10713/9950
dc.description.abstractEnvironmental factors can act as facilitators of chronic non-communicable diseases. Ambient noise and air pollution collectively outrank all other environmental risk factors in importance, contributing to over 75% of the disease and disability burden associated with known environmental risk factors. In the first part of this review, we discussed the global burden and epidemiologic evidence supporting the importance of these novel risk factors as facilitators of cardiometabolic disease. In this part, we will discuss pathophysiological mechanisms responsible for noise and air pollution-mediated effects. Akin to traditional cardiovascular risk factors, a considerable body of evidence suggests that these environmental agents induce low-grade inflammation, oxidative stress, vascular dysfunction, and autonomic nervous system imbalance, thereby facilitating the development of diseases such as hypertension and diabetes. Through their impact on traditional risk factors and via additional novel mechanisms, environmental risk factors may have much larger impact on cardiovascular events than currently appreciated. In the second part of this review, we discuss deficiencies and gaps in knowledge and opportunities for new research. Copyright The Author 2017.en_US
dc.description.urihttps://www.doi.org/10.1093/eurheartj/ehw294en_US
dc.language.isoen_USen_US
dc.publisherOxford University Pressen_US
dc.relation.ispartofEuropean Heart Journal
dc.subjectAir pollutionen_US
dc.subjectAtherosclerosisen_US
dc.subjectCardiometabolic diseaseen_US
dc.subjectCardiovascular risk factoren_US
dc.subjectEnvironmenten_US
dc.subjectInflammationen_US
dc.subjectNoiseen_US
dc.subjectOxidative stressen_US
dc.titleEnvironmental stressors and cardio-metabolic disease: Part II-mechanistic insightsen_US
dc.typeArticleen_US
dc.identifier.doi10.1093/eurheartj/ehw294
dc.identifier.pmid27460891


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