JournalPublic Health Genomics
PublisherS. Karger AG
MetadataShow full item record
AbstractSub-Saharan Africa (SSA) is experiencing a growing burden of cardiometabolic disorders, including diabetes, dyslipidemia, hypertension, obesity, coronary heart disease, and stroke. The increasing trends are expected to accelerate as SSA continues to experience economic progress, population growth, and the shift from communicable to noncommunicable diseases. These complex disorders are caused by multiple, potentially interacting, environmental, and genetic factors. While considerable progress has been made in the identification of the sociocultural, demographic, and lifestyle risk factors for cardiometabolic disorders, many genetic factors that underlie individual susceptibility to these diseases remain largely unknown. Although progress in genomic technologies has allowed for systematic characterization of genome-wide genetic diversity in health and disease in European and Asian ancestry populations, conduct of genetic studies in SSA has been underwhelming until recently. Here, we summarize recent understanding of the body of knowledge and highlight research opportunities on the genomics of cardiometabolic disorders in SSA. Copyright 2017 S. Karger AG, Basel.
SponsorsThis work was supported by the Intramural Research Program of the Center for Research on Genomics and Global Health. The Center for Research on Genomics and Global Health is supported by the National Human Genome Research Institute, the National Institute of Diabetes and Digestive and Kidney Diseases, the Center for Information Technology, and the Office of the Director at the National Institutes of Health (1ZIAHG200362-02). Sally Adebamowo was additionally supported by the Human Hereditary and Health in Africa, African Collaborative Center for Microbiome and Genomics Research Grant (1U54HG006947) funded by the National Institutes of Health/National Human Genome Research Institute.
Coronary heart disease
Identifier to cite or link to this itemhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85018704054&doi=10.1159%2f000468535&partnerID=40&md5=a476dcdc4f1905a92e2fc30f254d739d; http://hdl.handle.net/10713/9941