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    Predictors of adverse outcomes in children with Staphylococcus aureus Bacteremia

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    Author
    Kumarachandran, G.
    Johnson, J.K.
    Shirley, D.-A.
    Date
    2017
    Journal
    Journal of Pediatric Pharmacology and Therapeutics
    Publisher
    Pediatric Pharmacy Advocacy Group, Inc.
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://www.doi.org/10.5863/1551-6776-22.3.218
    Abstract
    OBJECTIVES Staphylococcus aureus bacteremia is a common infection, associated with significant morbidity and mortality in children. Factors associated with adverse treatment outcomes are poorly understood in the pediatric population. METHODS Our study compared clinical and microbiologic characteristics of children admitted during a 5-year period (2007�2012) to a large university-based hospital and found to have S aureus bacteremia with outcome measures, in order to identify risk factors associated with treatment failure (defined as 30-day mortality, delayed microbiologic resolution, or recurrence of S aureus bacteremia within 60 days of completing effective antibiotic therapy). RESULTS In all, 71 patients were found to have S aureus bacteremia, and of these, 17 patients (24%) experienced treatment failure. Based on the logistic regression model, only high vancomycin minimum inhibitory concentration in combination with a high-risk source of infection (i.e., infected graft or device, intra-abdominal infection, or respiratory tract infection) was significantly associated with risk of treatment failure. CONCLUSIONS Infection associated with a high-risk source may increase the chance of treatment failure in pediatric patients with S aureus bacteremia. Vancomycin minimum inhibitory concentration alone was not found to be a predictor of treatment outcomes. Copyright Published by the Pediatric Pharmacy Advocacy Group. All rights reserved.
    Keyword
    Adverse outcome
    Bacteremia
    Children
    MIC
    Staphylococcus aureus
    Vancomycin
    Identifier to cite or link to this item
    https://www.scopus.com/inward/record.uri?eid=2-s2.0-85041000489&doi=10.5863%2f1551-6776-22.3.218&partnerID=40&md5=f5982498557c356c14ffe7d8c34a50a5; http://hdl.handle.net/10713/9936
    ae974a485f413a2113503eed53cd6c53
    10.5863/1551-6776-22.3.218
    Scopus Count
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    UMB Open Access Articles 2017

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