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    A multi-national comparison of antipsychotic drug use in children and adolescents, 2005-2012

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    Author
    Kalverdijk, L.J.
    Bachmann, C.J.
    Aagaard, L.
    Date
    2017
    Journal
    Child and Adolescent Psychiatry and Mental Health
    Publisher
    BioMed Central Ltd.
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://www.doi.org/10.1186/s13034-017-0192-1
    Abstract
    Over the last decades, an increase in antipsychotic (AP) prescribing and a shift from first-generation antipsychotics (FGA) to second-generation antipsychotics (SGA) among youth have been reported. However, most AP prescriptions for youth are off-label, and there are worrying long-term safety data in youth. The objective of this study was to assess multinational trends in AP use among children and adolescents. A repeated cross-sectional design was applied to cohorts from varied sources from Denmark, Germany, the Netherlands, the United Kingdom (UK) and the United States (US) for calendar years 2005/2006-2012. The annual prevalence of AP use was assessed, stratified by age group, sex and subclass (FGA/SGA). The prevalence of AP use increased from 0.78 to 1.03% in the Netherlands' data, from 0.26 to 0.48% in the Danish cohort, from 0.23 to 0.32% in the German cohort, and from 0.1 to 0.14% in the UK cohort. In the US cohort, AP use decreased from 0.94 to 0.79%. In the US cohort, nearly all ATP dispensings were for SGA, while among the European cohorts the proportion of SGA dispensings grew to nearly 75% of all AP dispensings. With the exception of the Netherlands, AP use prevalence was highest in 15-19 year-olds. So, from 2005/6 to 2012, AP use prevalence increased in all youth cohorts from European countries and decreased in the US cohort. SGA were favoured in all countries' cohorts. Copyright 2017 The Author(s).
    Keyword
    Adolescents
    Antipsychotic drugs
    Atypical
    Children
    Denmark
    Germany
    Netherlands
    Pharmacoepidemiology
    UK
    USA
    Identifier to cite or link to this item
    https://www.scopus.com/inward/record.uri?eid=2-s2.0-85030848416&doi=10.1186%2fs13034-017-0192-1&partnerID=40&md5=536494a6460bda79a0d72418253a52e4; http://hdl.handle.net/10713/9925
    ae974a485f413a2113503eed53cd6c53
    10.1186/s13034-017-0192-1
    Scopus Count
    Collections
    UMB Open Access Articles 2017

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