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AbstractAt each of the brain's vast number of synapses, the presynaptic nerve terminal, synaptic cleft, and postsynaptic specialization form a transcellular unit to enable efficient transmission of information between neurons. While we know much about the molecular machinery within each compartment, we are only beginning to understand how these compartments are structurally registered and functionally integrated with one another. This review will describe the organization of each compartment and then discuss their alignment across pre- and postsynaptic cells at a nanometer scale. We propose that this architecture may allow for precise synaptic information exchange and may be modulated to contribute to the remarkable plasticity of brain function. Brain function relies on precise synaptic transmission. Biederer, Kaeser, and Blanpied describe the architecture of the nerve terminal, synaptic cleft, and postsynaptic density and the alignment of these compartments. This striking transcellular nanoscale organization may control synapse function. Copyright 2017 Elsevier Inc.
SponsorsThis work was supported by the NIH (grants R01NS083898 , R01MH113349 , and R01NS103484 to P.S.K., grant R01DA018928 to T.B., and grants R01MH080046 and R01MH111527 to T.A.B.).
Identifier to cite or link to this itemhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85033588204&doi=10.1016%2fj.neuron.2017.10.006&partnerID=40&md5=ff9526a2397a7c86fb2399dcb93494e7; http://hdl.handle.net/10713/9900
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