• Login
    View Item 
    •   UMB Digital Archive
    • UMB Open Access Articles
    • UMB Open Access Articles 2017
    • View Item
    •   UMB Digital Archive
    • UMB Open Access Articles
    • UMB Open Access Articles 2017
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of UMB Digital ArchiveCommunitiesPublication DateAuthorsTitlesSubjectsThis CollectionPublication DateAuthorsTitlesSubjects

    My Account

    LoginRegister

    Statistics

    Display statistics

    Reduction of pertussis inflammatory pathology by therapeutic treatment with sphingosine-1-phosphate receptor ligands by a pertussis toxin-Insensitive mechanism

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Author
    Skerry, C.
    Scanlon, K.
    Ardanuy, J.
    Date
    2017
    Journal
    Journal of Infectious Diseases
    Publisher
    Oxford University Press
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://www.doi.org/10.1093/infdis/jiw536
    Abstract
    Recent data have demonstrated the potential of sphingosine 1-phosphate (S1P) receptor (S1PR) agonism in the treatment of infectious diseases. A previous study used a murine model of Bordetella pertussis infection to demonstrate that treatment with the S1PR agonist AAL-R reduces pulmonary inflammation during infection. In the current study, we showed that this effect is mediated via the S1PR1 on LysM+ (myeloid) cells. Signaling via this receptor results in reduced lung inflammation and cellular recruitment as well as reduced morbidity and mortality in a neonatal mouse model of disease. Despite the fact that S1PRs are pertussis toxin-sensitive G protein-coupled receptors, the effects of AAL-R were pertussis toxin insensitive in our model. Furthermore, our data demonstrate that S1PR agonist administration may be effective at therapeutic time points. These results indicate a role for S1P signaling in B. pertussis-mediated pathology and highlight the possibility of host-Targeted therapy for pertussis. Copyright The Author 2017. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved.
    Sponsors
    This work was supported by the National Institute of Allergy and Infectious Diseases (Public Health Service grants AI-119566 and AI-117095.
    Keyword
    AAL-R
    Bordetella
    CYM-5442
    host-directed therapy
    Sphingosine 1-phosphate
    Identifier to cite or link to this item
    https://www.scopus.com/inward/record.uri?eid=2-s2.0-85021857586&doi=10.1093%2finfdis%2fjiw536&partnerID=40&md5=6249f1bb0136e3f2d27d3db8c5ceee88; http://hdl.handle.net/10713/9882
    ae974a485f413a2113503eed53cd6c53
    10.1093/infdis/jiw536
    Scopus Count
    Collections
    UMB Open Access Articles 2017

    entitlement

    Related articles

    • Sphingosine-1-phosphate Receptor Agonism Reduces Bordetella pertussis-mediated Lung Pathology.
    • Authors: Skerry C, Scanlon K, Rosen H, Carbonetti NH
    • Issue date: 2015 Jun 15
    • Peptidoglycan Recognition Protein 4 Suppresses Early Inflammatory Responses to <i>Bordetella pertussis</i> and Contributes to Sphingosine-1-Phosphate Receptor Agonist-Mediated Disease Attenuation.
    • Authors: Skerry C, Goldman WE, Carbonetti NH
    • Issue date: 2019 Feb
    • Epithelial anion transporter pendrin contributes to inflammatory lung pathology in mouse models of Bordetella pertussis infection.
    • Authors: Scanlon KM, Gau Y, Zhu J, Skerry C, Wall SM, Soleimani M, Carbonetti NH
    • Issue date: 2014 Oct
    • Sphingosine 1-phosphate enhances the excitability of rat sensory neurons through activation of sphingosine 1-phosphate receptors 1 and/or 3.
    • Authors: Li C, Li JN, Kays J, Guerrero M, Nicol GD
    • Issue date: 2015 Apr 12
    • Differential effects of sphingosine 1-phosphate receptors on airway and vascular barrier function in the murine lung.
    • Authors: Sammani S, Moreno-Vinasco L, Mirzapoiazova T, Singleton PA, Chiang ET, Evenoski CL, Wang T, Mathew B, Husain A, Moitra J, Sun X, Nunez L, Jacobson JR, Dudek SM, Natarajan V, Garcia JG
    • Issue date: 2010 Oct
    DSpace software (copyright © 2002 - 2021)  DuraSpace
    Quick Guide | Policies | Contact Us | UMB Health Sciences & Human Services Library
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.