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dc.contributor.authorYerges-Armstrong, Laura M.
dc.contributor.authorZillikens, Maria Carola
dc.contributor.authorKiel, Douglas P.
dc.date.accessioned2019-07-11T19:48:16Z
dc.date.available2019-07-11T19:48:16Z
dc.date.issued2017-12
dc.identifier.urihttp://hdl.handle.net/10713/9869
dc.descriptionCorrection for this article is at https://www.doi.org/10.1038/s41467-017-01008-2.en_US
dc.description.abstractLean body mass, consisting mostly of skeletal muscle, is important for healthy aging. We performed a genome-wide association study for whole body (20 cohorts of European ancestry with n = 38,292) and appendicular (arms and legs) lean body mass (n = 28,330) measured using dual energy X-ray absorptiometry or bioelectrical impedance analysis, adjusted for sex, age, height, and fat mass. Twenty-one single-nucleotide polymorphisms were significantly associated with lean body mass either genome wide (p < 5 × 10-8) or suggestively genome wide (p < 2.3 × 10-6). Replication in 63,475 (47,227 of European ancestry) individuals from 33 cohorts for whole body lean body mass and in 45,090 (42,360 of European ancestry) subjects from 25 cohorts for appendicular lean body mass was successful for five single-nucleotide polymorphisms in/near HSD17B11, VCAN, ADAMTSL3, IRS1, and FTO for total lean body mass and for three single-nucleotide polymorphisms in/near VCAN, ADAMTSL3, and IRS1 for appendicular lean body mass. Our findings provide new insight into the genetics of lean body mass. © 2017 The Author(s).en_US
dc.description.urihttps://doi.org/10.1038/s41467-017-00031-7en_US
dc.description.urihttps://doi.org/10.1038/s41467-017-01008-2en_US
dc.language.isoen_USen_US
dc.publisherNature Publishing Groupen_US
dc.relation.ispartofNature Communicationsen_US
dc.subject.mesh17-Hydroxysteroid Dehydrogenasesen_US
dc.subject.meshAldehyde Oxidoreductasesen_US
dc.subject.meshAlpha-Ketoglutarate-Dependent Dioxygenase FTOen_US
dc.subject.meshBody Compositionen_US
dc.subject.meshExtracellular Matrix Proteinsen_US
dc.subject.meshGenome-Wide Association Studyen_US
dc.subject.meshInsulin Receptor Substrate Proteinsen_US
dc.subject.meshPolymorphism, Single Nucleotideen_US
dc.subject.meshQuantitative Trait Locien_US
dc.titleLarge meta-analysis of genome-wide association studies identifies five loci for lean body massen_US
dc.typeArticleen_US
dc.identifier.doi10.1038/s41467-017-00031-7
dc.identifier.pmid8724990


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