Evaluation of a booster dose of pentavalent rotavirus vaccine coadministered with measles, yellow fever, and meningitis a Vaccines in 9-Month-old malian infants
| dc.contributor.author | Tapia, Milagritos D. | |
| dc.contributor.author | Sow, Samba O. | |
| dc.contributor.author | Fitzpatrick, Meagan | |
| dc.contributor.author | Neuzil, Kathleen M. | |
| dc.contributor.author | Kotloff, Karen L. | |
| dc.creator | Haidara, F. | |
| dc.date.accessioned | 2019-07-08T19:10:02Z | |
| dc.date.available | 2019-07-08T19:10:02Z | |
| dc.date.issued | 2018-07-13 | |
| dc.identifier.uri | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85050812440&origin=inward | |
| dc.identifier.uri | http://hdl.handle.net/10713/9863 | |
| dc.description | The trial was registered with ClinicalTrials.gov (NCT02286895). | en_US |
| dc.description | Correction for this article is at https://www.doi.org/10.1093/infdis/jiy540. | |
| dc.description.abstract | Background Rotavirus vaccines given to infants are safe and efficacious. A booster dose of rotavirus vaccine could extend protection into the second year of life in low-resource countries. Methods We conducted an open-label, individual-randomized trial in Bamako, Mali. We assigned 600 infants aged 9-11 months to receive measles vaccine (MV), yellow fever vaccine (YFV), and meningococcal A conjugate vaccine (MenAV) with or without pentavalent rotavirus vaccine (PRV). We assessed the noninferiority (defined as a difference of ≤10%) of seroconversion and seroresponse rates to MV, YFV, and MenAV. We compared the seroresponse to PRV. Results Seroconversion to MV occurred in 255 of 261 PRV recipients (97.7%) and 246 of 252 control infants (97.6%; difference, 0.1% [95% confidence interval {CI}, -4.0%-4.2%]). Seroresponse to YFV occurred in 48.1% of PRV recipients (141 of 293), compared with 52.2% of controls (153 of 293; difference, -4.1% [95% CI, -12.2%-4.0%]). A 4-fold rise in meningococcus A bactericidal titer was observed in 273 of 292 PRV recipients (93.5%) and 276 of 293 controls (94.2%; difference, -0.7% [95% CI, -5.2%-3.8%]). Rises in geometric mean concentrations of immunoglobulin A and immunoglobulin G antibodies to rotavirus were higher among PRV recipients (118 [95% CI, 91-154] and 364 [95% CI, 294-450], respectively), compared with controls (68 [95% CI, 50-92] and 153 [95% CI, 114-207], respectively). Conclusions PRV did not interfere with MV and MenAV; this study could not rule out interference with YFV. PRV increased serum rotavirus antibody levels. Clinical Trials Registration NCT02286895. © The Author(s) 2018. | en_US |
| dc.description.sponsorship | This work was supported by PATH and the Bill and Melinda Gates Foundation. | en_US |
| dc.description.uri | https://www.doi.org/10.1093/infdis/jiy215 | en_US |
| dc.description.uri | https://www.doi.org/10.1093/infdis/jiy540 | en_US |
| dc.language.iso | en_US | en_US |
| dc.publisher | Oxford University Press | en_US |
| dc.relation.ispartof | Journal of Infectious Diseases | en_US |
| dc.subject | booster dose | en_US |
| dc.subject | infants | en_US |
| dc.subject | Mali | en_US |
| dc.subject | measles vaccine | en_US |
| dc.subject | Rotavirus vaccine | en_US |
| dc.subject | yellow fever vaccine | en_US |
| dc.title | Evaluation of a booster dose of pentavalent rotavirus vaccine coadministered with measles, yellow fever, and meningitis a Vaccines in 9-Month-old malian infants | en_US |
| dc.type | Article | en_US |
| dc.identifier.doi | 10.1093/infdis/jiy215 | |
| dc.identifier.doi | 10.1093/infdis/jiy540 | |
| dc.identifier.pmid | 29659924 | |
| dc.relation.volume | 218 |
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