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    Statins exacerbate glucose intolerance and hyperglycemia in a high sucrose fed rodent model

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    Author
    Seshadri, Sriram
    Rapaka, Naimisha
    Kapadia, Bandish
    Date
    2019-12-01
    Journal
    Scientific Reports
    Publisher
    Nature Publishing Group
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.1038/s41598-019-45369-8
    Abstract
    Statins are first-line therapy drugs for cholesterol lowering. While they are highly effective at lowering cholesterol, they have propensity to induce hyperglycemia in patients. Only limited studies have been reported which studied the impact of statins on (a) whether they can worsen glucose tolerance in a high sucrose fed animal model and (b) if so, what could be the molecular mechanism. We designed studies using high sucrose fed animals to explore the above questions. The high sucrose fed animals were treated with atorvastatin and simvastatin, the two most prescribed statins. We examined the effects of statins on hyperglycemia, glucose tolerance, fatty acid accumulation and insulin signaling. We found that chronic treatment with atorvastatin made the animals hyperglycemic and glucose intolerant in comparison with diet alone. Treatment with both statins lead to fatty acid accumulation and inhibition of insulin signaling in the muscle tissue at multiple points in the pathway. © 2019, The Author(s).
    Sponsors
    Financial support from DBT, India (BT/PR15214/BRB/10/903/2011) and DST-SERB, India (EMR/2016/002140).
    Keyword
    statins
    Glucose Intolerance
    Hydroxymethylglutaryl-CoA Reductase Inhibitors
    Hyperglycemia
    Identifier to cite or link to this item
    https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85067799318&origin=inward; http://hdl.handle.net/10713/9853
    ae974a485f413a2113503eed53cd6c53
    10.1038/s41598-019-45369-8
    Scopus Count
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    UMB Open Access Articles 2019

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