Genomic structure and diversity of Plasmodium falciparum in Southeast Asia reveal recent parasite migration patterns
PublisherNature Publishing Group
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AbstractEstimates of Plasmodium falciparum migration may inform strategies for malaria elimination. Here we elucidate fine-scale parasite population structure and infer recent migration across Southeast Asia using identity-by-descent (IBD) approaches based on genome-wide single nucleotide polymorphisms called in 1722 samples from 54 districts. IBD estimates are consistent with isolation-by-distance. We observe greater sharing of larger IBD segments between artemisinin-resistant parasites versus sensitive parasites, which is consistent with the recent spread of drug resistance. Our IBD analyses reveal actionable patterns, including isolated parasite populations, which may be prioritized for malaria elimination, as well as asymmetrical migration identifying potential sources and sinks of migrating parasites. © 2019, The Author(s).
SponsorsThis work was supported by NIH R03-AI101680, NIH R01-AI101713, NIH U19AI129386, and NIH U19AI110820 granted by the U.S. National Institutes of Health (NIH), the Intramural Research Program of the National Institute of Allergy and Infectious Diseases, NIH, USA, the Bill & Melinda Gates Foundation (OPP1171753) and the Howard Hughes Medical Institute.
Identifier to cite or link to this itemhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85067602013&origin=inward; http://hdl.handle.net/10713/9852