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dc.contributor.authorSah, Pratha
dc.contributor.authorMedlock, Jan
dc.contributor.authorFitzpatrick, Meagan C.
dc.creatorSah, P.
dc.date.accessioned2019-07-01T19:55:35Z
dc.date.available2019-07-01T19:55:35Z
dc.date.issued2018-05-15
dc.identifier.urihttp://hdl.handle.net/10713/9849
dc.description.abstractThe efficacy of influenza vaccines varies from one year to the next, with efficacy during the 2017–2018 season anticipated to be lower than usual. However, the impact of low-efficacy vaccines at the population level and their optimal age-specific distribution have yet to be ascertained. Applying an optimization algorithm to a mathematical model of influenza transmission and vaccination in the United States, we determined the optimal age-specific uptake of low-efficacy vaccine that would minimize incidence, hospitalization, mortality, and disability-adjusted life-years (DALYs), respectively. We found that even relatively low-efficacy influenza vaccines can be highly impactful, particularly when vaccine uptake is optimally distributed across age groups. As vaccine efficacy declines, the optimal distribution of vaccine uptake shifts toward the elderly to minimize mortality and DALYs. Health practitioner encouragement and concerted recruitment efforts are required to achieve optimal coverage among target age groups, thereby minimizing influenza morbidity and mortality for the population overall.en_US
dc.description.sponsorshipSupported by National Institutes of Health Grants U01 GM105627 and U01 GM087719.en_US
dc.description.urihttps://www.doi.org/10.1073/pnas.1802479115en_US
dc.language.isoen_USen_US
dc.publisherNational Academy of Sciencesen_US
dc.relation.ispartofProceedings of the National Academy of Sciences of the United States of Americaen_US
dc.subjectAge structureden_US
dc.subjectDALYen_US
dc.subjectHospitalizationen_US
dc.subjectMathematical modelen_US
dc.subjectVaccinationen_US
dc.titleOptimizing the impact of low-efficacy influenza vaccinesen_US
dc.typeArticleen_US
dc.identifier.doi10.1073/pnas.1802479115
dc.identifier.pmid29712866
dc.relation.volume115


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