• Login
    View Item 
    •   UMB Digital Archive
    • UMB Open Access Articles
    • UMB Open Access Articles
    • View Item
    •   UMB Digital Archive
    • UMB Open Access Articles
    • UMB Open Access Articles
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of UMB Digital ArchiveCommunitiesPublication DateAuthorsTitlesSubjectsThis CollectionPublication DateAuthorsTitlesSubjects

    My Account

    LoginRegister

    Statistics

    Display statistics

    Optimizing the impact of low-efficacy influenza vaccines

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Author
    Sah, Pratha
    Medlock, Jan
    Fitzpatrick, Meagan C.
    Date
    2018-05-15
    Journal
    Proceedings of the National Academy of Sciences of the United States of America
    Publisher
    National Academy of Sciences
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://www.doi.org/10.1073/pnas.1802479115
    Abstract
    The efficacy of influenza vaccines varies from one year to the next, with efficacy during the 2017–2018 season anticipated to be lower than usual. However, the impact of low-efficacy vaccines at the population level and their optimal age-specific distribution have yet to be ascertained. Applying an optimization algorithm to a mathematical model of influenza transmission and vaccination in the United States, we determined the optimal age-specific uptake of low-efficacy vaccine that would minimize incidence, hospitalization, mortality, and disability-adjusted life-years (DALYs), respectively. We found that even relatively low-efficacy influenza vaccines can be highly impactful, particularly when vaccine uptake is optimally distributed across age groups. As vaccine efficacy declines, the optimal distribution of vaccine uptake shifts toward the elderly to minimize mortality and DALYs. Health practitioner encouragement and concerted recruitment efforts are required to achieve optimal coverage among target age groups, thereby minimizing influenza morbidity and mortality for the population overall.
    Sponsors
    Supported by National Institutes of Health Grants U01 GM105627 and U01 GM087719.
    Keyword
    Age structured
    DALY
    Hospitalization
    Mathematical model
    Vaccination
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/9849
    ae974a485f413a2113503eed53cd6c53
    10.1073/pnas.1802479115
    Scopus Count
    Collections
    UMB Open Access Articles

    entitlement

    Related articles

    • Future epidemiological and economic impacts of universal influenza vaccines.
    • Authors: Sah P, Alfaro-Murillo JA, Fitzpatrick MC, Neuzil KM, Meyers LA, Singer BH, Galvani AP
    • Issue date: 2019 Oct 8
    • Vaccines for seasonal and pandemic influenza.
    • Authors: Nichol KL, Treanor JJ
    • Issue date: 2006 Nov 1
    • Establishing the health and economic impact of influenza vaccination within the European Union 25 countries.
    • Authors: Ryan J, Zoellner Y, Gradl B, Palache B, Medema J
    • Issue date: 2006 Nov 17
    • Surveillance of influenza vaccination coverage--United States, 2007-08 through 2011-12 influenza seasons.
    • Authors: Lu PJ, Santibanez TA, Williams WW, Zhang J, Ding H, Bryan L, O'Halloran A, Greby SM, Bridges CB, Graitcer SB, Kennedy ED, Lindley MC, Ahluwalia IB, LaVail K, Pabst LJ, Harris L, Vogt T, Town M, Singleton JA, Centers for Disease Control and Prevention (CDC).
    • Issue date: 2013 Oct 25
    • Optimizing influenza vaccine distribution.
    • Authors: Medlock J, Galvani AP
    • Issue date: 2009 Sep 25
    DSpace software (copyright © 2002 - 2022)  DuraSpace
    Quick Guide | Policies | Contact Us | UMB Health Sciences & Human Services Library
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.