Show simple item record

dc.contributor.authorChen, Wilbur H.
dc.contributor.authorSztein, Marcelo B.
dc.contributor.authorLevine, Myron M.
dc.creatorHaney, D.
dc.date.accessioned2019-07-01T19:50:21Z
dc.date.available2019-07-01T19:50:21Z
dc.date.issued2018-05-11
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85045205035&origin=inward
dc.identifier.urihttp://hdl.handle.net/10713/9848
dc.description.abstractBackground: The single-dose live attenuated vaccine CVD 103-HgR protects against experimental Vibrio cholerae infection in cholera-naïve adults for at least 6 months after vaccination. While vaccine-induced vibriocidal seroconversion is associated with protection, vibriocidal titers decline rapidly from their peak 1–2 weeks after vaccination. Although vaccine-induced memory B cells (MBCs) might mediate sustained protection in individuals without detectable circulating antibodies, it is unknown whether oral cholera vaccination induces a MBC response. Methods: In a study that enrolled North American adults, we measured lipopolysaccharide (LPS)- and cholera toxin (CtxB)-specific MBC responses to PXVX0200 (derived from the CVD 103-HgR strain) and assessed stool volumes following experimental Vibrio cholerae infection. We then evaluated the association between vaccine-induced MBC responses and protection against cholera. Results: There was a significant increase in % CT-specific IgG, % LPS-specific IgG, and % LPS-specific IgA MBCs which persisted 180 days after vaccination as well as a significant association between vaccine-induced increase in % LPS-specific IgA MBCs and lower post-challenge stool volume (r = −0.56, p < 0.001). Discussion: Oral cholera vaccination induces antigen-specific MBC responses, and the anamnestic LPS-specific responses may contribute to long-term protection and provide correlates of the duration of vaccine-induced protection. Clinical trials registration: NCT01895855. © 2018 The Author(s)en_US
dc.description.sponsorshipThis work was supported, in part, by the National Institute of Allergy and Infectious Diseases , National Institutes of Health grant number U19 AI-082655 to MBS and AI103055 to JBH .en_US
dc.description.urihttps://www.doi.org/10.1016/j.vaccine.2018.04.011en_US
dc.language.isoen_USen_US
dc.publisherElsevier Ltd.en_US
dc.relation.ispartofVaccineen_US
dc.subjectCholeraen_US
dc.subjectCholera-naïveen_US
dc.subjectCVD 103-HgRen_US
dc.subjectDuration of protectionen_US
dc.subjectLive vaccineen_US
dc.subjectMemory B cellsen_US
dc.titleLipopolysaccharide-specific memory B cell responses to an attenuated live cholera vaccine are associated with protection against Vibrio cholerae infectionen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.vaccine.2018.04.011
dc.identifier.pmid29655627
dc.relation.volume36


Files in this item

Thumbnail
Name:
Publisher version

This item appears in the following Collection(s)

Show simple item record