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dc.contributor.authorCole, John W.
dc.contributor.authorMitchell, Braxton D.
dc.contributor.authorMcArdle, Patrick F.
dc.contributor.authorCheng, Yu-Ching
dc.contributor.authorStine, O. Colin
dc.date.accessioned2019-06-25T14:46:18Z
dc.date.available2019-06-25T14:46:18Z
dc.date.issued2019-06-03
dc.identifier.urihttp://hdl.handle.net/10713/9820
dc.descriptionCorrection to: Nature Genetics https://doi.org/10.1038/s41588-018-0058-3, published online 12 March 2018.en_US
dc.descriptionPublisher correction (in the order of author names) at https://doi.org/10.1038/s41588-019-0449-0en_US
dc.description.abstractStroke has multiple etiologies, but the underlying genes and pathways are largely unknown. We conducted a multiancestry genome-wide-association meta-analysis in 521,612 individuals (67,162 cases and 454,450 controls) and discovered 22 new stroke risk loci, bringing the total to 32. We further found shared genetic variation with related vascular traits, including blood pressure, cardiac traits, and venous thromboembolism, at individual loci (n= 18), and using genetic risk scores and linkagedisequilibrium-score regression. Several loci exhibited distinct association and pleiotropy patterns for etiological stroke subtypes. Eleven new susceptibility loci indicate mechanisms not previously implicated in stroke pathophysiology, with prioritization of risk variants and genes accomplished through bioinformatics analyses using extensive functional datasets. Stroke risk loci were significantly enriched in drug targets for antithrombotic therapy.en_US
dc.description.urihttps://doi.org/10.1038/s41588-018-0058-3en_US
dc.description.urihttps://doi.org/10.1038/s41588-019-0449-0en_US
dc.language.isoen_USen_US
dc.publisherNature Publishing Groupen_US
dc.relation.ispartofNature Geneticsen_US
dc.subjectGeneticsen_US
dc.subjectGenome-wide association studiesen_US
dc.subjectStrokeen_US
dc.titleMultiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypesen_US
dc.typeArticleen_US
dc.identifier.doi10.1038/s41588-018-0058-3
dc.identifier.doi10.1038/s41588-019-0449-0


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