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    Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes

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    Author
    Cole, John W.
    Mitchell, Braxton D.
    McArdle, Patrick F.
    Cheng, Yu-Ching
    Stine, O. Colin
    Date
    2019-06-03
    Journal
    Nature Genetics
    Publisher
    Nature Publishing Group
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.1038/s41588-018-0058-3
    https://doi.org/10.1038/s41588-019-0449-0
    Abstract
    Stroke has multiple etiologies, but the underlying genes and pathways are largely unknown. We conducted a multiancestry genome-wide-association meta-analysis in 521,612 individuals (67,162 cases and 454,450 controls) and discovered 22 new stroke risk loci, bringing the total to 32. We further found shared genetic variation with related vascular traits, including blood pressure, cardiac traits, and venous thromboembolism, at individual loci (n= 18), and using genetic risk scores and linkagedisequilibrium-score regression. Several loci exhibited distinct association and pleiotropy patterns for etiological stroke subtypes. Eleven new susceptibility loci indicate mechanisms not previously implicated in stroke pathophysiology, with prioritization of risk variants and genes accomplished through bioinformatics analyses using extensive functional datasets. Stroke risk loci were significantly enriched in drug targets for antithrombotic therapy.
    Description
    Correction to: Nature Genetics https://doi.org/10.1038/s41588-018-0058-3, published online 12 March 2018.
    Publisher correction (in the order of author names) at https://doi.org/10.1038/s41588-019-0449-0
    Keyword
    Genetics
    Genome-wide association studies
    Stroke
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/9820
    ae974a485f413a2113503eed53cd6c53
    10.1038/s41588-018-0058-3
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