A Comprehensive Pan-Cancer Molecular Study of Gynecologic and Breast Cancers
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Abstract
We analyzed molecular data on 2,579 tumors from The Cancer Genome Atlas (TCGA) of four gynecological types plus breast. Our aims were to identify shared and unique molecular features, clinically significant subtypes, and potential therapeutic targets. We found 61 somatic copy-number alterations (SCNAs) and 46 significantly mutated genes (SMGs). Eleven SCNAs and 11 SMGs had not been identified in previous TCGA studies of the individual tumor types. We found functionally significant estrogen receptor-regulated long non-coding RNAs (lncRNAs) and gene/lncRNA interaction networks. Pathway analysis identified subtypes with high leukocyte infiltration, raising potential implications for immunotherapy. Using 16 key molecular features, we identified five prognostic subtypes and developed a decision tree that classified patients into the subtypes based on just six features that are assessable in clinical laboratories. By performing molecular analyses of 2,579 TCGA gynecological (OV, UCEC, CESC, and UCS) and breast tumors, Berger et al. identify five prognostic subtypes using 16 key molecular features and propose a decision tree based on six clinically assessable features that classifies patients into the subtypes. Copyright 2018 Elsevier Inc.Sponsors
This work was supported by the following NCI grants: U54 HG003273 , U54 HG003067 , U54 HG003079 , U24 CA143799 , U24 CA143835 , U24 CA143840 , U24 CA143843 , U24 CA143845 , U24 CA143848 , U24 CA143858 , U24 CA143866 , U24 CA143867 , U24 CA143882 , U24 CA143883 , U24 CA144025 , U24 CA210949 , U24 CA210950 , P30 CA016672 , P50 CA136393 .Keyword
breast cancercervical cancer
gynecologic cancer
omics
ovarian cancer
pan-gynecologic
TCGA
The Cancer Genome Atlas
uterine cancer
uterine carcinosarcoma
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85044909989&doi=10.1016%2fj.ccell.2018.03.014&partnerID=40&md5=1d2499b2d0ff55b804214c03e41f81c6; http://hdl.handle.net/10713/9810Scopus Count
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