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    Donor Experiences of Second Marrow or Peripheral Blood Stem Cell Collection Mirror the First, but CD34 + Yields Are Less

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    Author
    Stroncek, D.F.
    Shaw, B.E.
    Logan, B.R.
    Date
    2018
    Journal
    Biology of Blood and Marrow Transplantation
    Publisher
    Elsevier Inc.
    Type
    Article
    
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    See at
    https://dx.doi.org/10.1016/j.bbmt.2017.09.013
    Abstract
    Little is known about the experiences of individuals donating peripheral blood stem cells (PBSCs) or marrow for a second time. To study this, unrelated donors making a second donation through the National Marrow Donor Program between 2004 and 2013 were evaluated. Experiences of second-time donors giving marrow (n = 118: first donation was PBSC in 76 and marrow in 42) were compared with those making only 1 marrow donation (n = 5829). Experiences of second-time donors giving PBSCs (n = 602) (first donation was PBSCs in 362; marrow in 240) were compared to first-time PBSC donors (n = 16,095). For donors giving a second PBSC or marrow donation there were no significant differences in maximum skeletal pain, maximum symptoms measured by an established modified toxicity criteria, and recovery time compared with those who donated only once. Notably, the yield of marrow nucleated cells and PBSC CD34 + cells with second donations was less. As previously noted with single first-time donations, female (PBSCs and marrow) and obese donors (PBSCs) had higher skeletal pain and/or toxicity with a second donation. PBSC donors who experienced high levels of pain or toxicity with the first donation also experienced high levels of these symptoms with their second donation and slower recovery times. In conclusion, for most donors second donation experiences were similar to first donation experiences, but CD34 + yields were less. Knowledge of the donor's first experience and stem cell yields may help centers decide whether second donations are appropriate and institute measures to improve donor experiences. Copyright 2017 The American Society for Blood and Marrow Transplantation
    Keyword
    Bone marrow
    Hematopoietic cell transplantation
    Peripheral blood stem cells
    Unrelated donor
    Identifier to cite or link to this item
    https://www.scopus.com/inward/record.uri?eid=2-s2.0-85033230771&doi=10.1016%2fj.bbmt.2017.09.013&partnerID=40&md5=44f880f5f93fd7b2b1398c6a28329969; http://hdl.handle.net/10713/9771
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.bbmt.2017.09.013
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