Precision Medicine for CRC Patients in the Veteran Population: State-of-the-Art, Challenges and Research Directions
JournalDigestive Diseases and Sciences
PublisherSpringer New York LLC
MetadataShow full item record
AbstractColorectal cancer (CRC) accounts for ~9% of all cancers in the Veteran population, a fact which has focused a great deal of the attention of the VA's research and development efforts. A field-based meeting of CRC experts was convened to discuss both challenges and opportunities in precision medicine for CRC. This group, designated as the VA Colorectal Cancer Cell-genomics Consortium (VA4C), discussed advances in CRC biology, biomarkers, and imaging for early detection and prevention. There was also a discussion of precision treatment involving fluorescence-guided surgery, targeted chemotherapies and immunotherapies, and personalized cancer treatment approaches. The overarching goal was to identify modalities that might ultimately lead to personalized cancer diagnosis and treatment. This review summarizes the findings of this VA field-based meeting, in which much of the current knowledge on CRC prescreening and treatment was discussed. It was concluded that there is a need and an opportunity to identify new targets for both the prevention of CRC and the development of effective therapies for advanced disease. Also, developing methods integrating genomic testing with tumoroid-based clinical drug response might lead to more accurate diagnosis and prognostication and more effective personalized treatment of CRC. Copyright 2018, The Author(s).
SponsorsThis VA Colorectal Cancer Cell-genomics Consortium (VA4C) meeting was supported by a Department of Veterans Affairs Biomedical Laboratory Research and Development Service field-based meeting award to Dr. Shyam Mohapatra and Dr. Subhra Mohapatra.
Cancer stem cells
Clinical drug response
Next generation sequencing
Precision Oncology Program (POP)
Identifier to cite or link to this itemhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85044377881&doi=10.1007%2fs10620-018-5000-0&partnerID=40&md5=cc481dd0d45e147906d6468214146add; http://hdl.handle.net/10713/9724