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    Prevalence of asymptomatic parasitemia and gametocytemia in hiv-infected children on differing antiretroviral therapy

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    Author
    Hobbs, C.V.
    Gabriel, E.E.
    Kamthunzi, P.
    Date
    2018
    Journal
    American Journal of Tropical Medicine and Hygiene
    Publisher
    American Society of Tropical Medicine and Hygiene
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://dx.doi.org/10.4269/ajtmh.17-0462
    Abstract
    Laboratory data and prior pediatric reports indicate that HIV protease inhibitor (PI)-based antiretroviral therapy (ARV) kills gametocytes and reduces rates of gametocytemia, but not asymptomatic parasitemia, in a high malaria-transmission area. To determine whether ARV regimen impacts these rates in areas with less-intense malaria transmission, we compared asymptomatic parasitemia and gametocytemia rates in HIV-infected children by ARV regimen in Lilongwe, Malawi, an area of low-to-moderate transmission intensity. HIV PI lopinavir-ritonavir (LPV-rtv) ARV-or non-nucleoside reverse transcriptase inhibitor nevirapine ARV-treated children did not differ in the rates of polymerase chain reaction-detected asymptomatic parasitemia (relative risk [RR] 0.43 95% confidence interval [CI] [0.16, 1.18], P value 0.10) or microscopically detected gametocytemia with LPV-rtv ARV during symptomatic malaria (RR 0.4895%CI [0.22,1.04] P value 0.06). LPV-rtv ARV was not associated with reduced rates of asymptomatic parasitemia, or gametocytemia on days of symptomatic malaria episodes, in HIV-infected children. Larger studies should evaluate whether ARV impacts transmission. Copyright 2018 by The American Society of Tropical Medicine and Hygiene.
    Keyword
    gametocytemia
    Children
    Antiretroviral Therapy, Highly Active
    HIV Protease Inhibitors
    Parasitemia
    Plasmodium
    Identifier to cite or link to this item
    https://www.scopus.com/inward/record.uri?eid=2-s2.0-85040523044&doi=10.4269%2fajtmh.17-0462&partnerID=40&md5=3fede9ec56890a6ef3a81ad7c5665f98; http://hdl.handle.net/10713/9713
    ae974a485f413a2113503eed53cd6c53
    10.4269/ajtmh.17-0462
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