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dc.contributor.authorHarris, D.N.
dc.contributor.authorSong, W.
dc.contributor.authorShetty, A.C.
dc.date.accessioned2019-06-21T18:46:28Z
dc.date.available2019-06-21T18:46:28Z
dc.date.issued2018
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85049612491&doi=10.1073%2fpnas.1720798115&partnerID=40&md5=56c82a0ef7e4b7d141d8950af1ee5898
dc.identifier.urihttp://hdl.handle.net/10713/9711
dc.description.abstractNative Americans from the Amazon, Andes, and coastal geographic regions of South America have a rich cultural heritage but are genetically understudied, therefore leading to gaps in our knowledge of their genomic architecture and demographic history. In this study, we sequence 150 genomes to high coverage combined with an additional 130 genotype array samples from Native American and mestizo populations in Peru. The majority of our samples possess greater than 90% Native American ancestry, which makes this the most extensive Native American sequencing project to date. Demographic modeling reveals that the peopling of Peru began by 12,000 y ago, consistent with the hypothesis of the rapid peopling of the Americas and Peruvian archeological data. We find that the Native American populations possess distinct ancestral divisions, whereas the mestizo groups were admixtures of multiple Native American communities that occurred before and during the Inca Empire and Spanish rule. In addition, the mestizo communities also show Spanish introgression largely following Peruvian Independence, nearly 300 y after Spain conquered Peru. Further, we estimate migration events between Peruvian populations from all three geographic regions with the majority of between-region migration moving from the high Andes to the low-altitude Amazon and coast. As such, we present a detailed model of the evolutionary dynamics which impacted the genomes of modern-day Peruvians and a Native American ancestry dataset that will serve as a beneficial resource to addressing the underrepresentation of Native American ancestry in sequencing studies.en_US
dc.description.urihttps://dx.doi.org/10.1073/pnas.1720798115en_US
dc.language.isoen-USen_US
dc.publisherNational Academy of Sciencesen_US
dc.relation.ispartofProceedings of the National Academy of Sciences of the United States of America
dc.subjectFine-scale structureen_US
dc.subjectGene flowen_US
dc.subjectIdentity by descenten_US
dc.subjectNative American demographyen_US
dc.subjectPopulation historyen_US
dc.titleEvolutionary genomic dynamics of Peruvians before, during, and after the Inca Empireen_US
dc.typeArticleen_US
dc.identifier.doi10.1073/pnas.1720798115
dc.identifier.pmid29946025


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