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dc.contributor.authorRoesch, C.
dc.contributor.authorPopovici, J.
dc.contributor.authorBin, S.
dc.date.accessioned2019-06-21T18:46:27Z
dc.date.available2019-06-21T18:46:27Z
dc.date.issued2018
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85055901505&doi=10.1371%2fjournal.pntd.0006555&partnerID=40&md5=e94be0cdc6d09b5a7cc0505e1aba957f
dc.identifier.urihttp://hdl.handle.net/10713/9701
dc.description.abstractThe interaction between Plasmodium vivax Duffy binding protein (PvDBP) and Duffy antigen receptor for chemokines (DARC) has been described as critical for the invasion of human reticulocytes, although increasing reports of P. vivax infections in Duffy-negative individuals questions its unique role. To investigate the genetic diversity of the two main protein ligands for reticulocyte invasion, PvDBP and P. vivax Erythrocyte Binding Protein (PvEBP), we analyzed 458 isolates collected in Cambodia and Madagascar from individuals genotyped as Duffy-positive. First, we observed a high proportion of isolates with multiple copies PvEBP from Madagascar (56%) where Duffy negative and positive individuals coexist compared to Cambodia (19%) where Duffy-negative population is virtually absent. Whether the gene amplification observed is responsible for alternate invasion pathways remains to be tested. Second, we found that the PvEBP gene was less diverse than PvDBP gene (12 vs. 33 alleles) but provided evidence for an excess of nonsynonymous mutations with the complete absence of synonymous mutations. This finding reveals that PvEBP is under strong diversifying selection, and confirms the importance of this protein ligand in the invasion process of the human reticulocytes and as a target of acquired immunity. These observations highlight how genomic changes in parasite ligands improve the fitness of P. vivax isolates in the face of immune pressure and receptor polymorphisms.en_US
dc.description.urihttps://dx.doi.org/10.1371/journal.pntd.0006555en_US
dc.language.isoen-USen_US
dc.publisherPublic Library of Scienceen_US
dc.relation.ispartofPLoS neglected tropical diseases
dc.subject.meshDuffy Blood-Group System--immunologyen_US
dc.subject.meshLigandsen_US
dc.subject.meshPlasmodium vivax--geneticsen_US
dc.subject.meshPolymorphism, Geneticen_US
dc.subject.meshReticulocytesen_US
dc.titleGenetic diversity in two Plasmodium vivax protein ligands for reticulocyte invasionen_US
dc.typeArticleen_US
dc.identifier.doi10.1371/journal.pntd.0006555
dc.identifier.pmid30346980


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